Detail

Chr	chr21
start	42599280
end	42615058
lncRNA name	BC041455
entrez id	101928233
hgnc id	HGNC:52459
ensg id	ENSG00000225431
refseq id	NR_131192
methods	microarray, qPCR, RNAi, Western blot etc.
regulated	down-regulated
function description	From these 127 DE lncRNAs, we selected the top 25 most significant genes for further validation and analysis (electronic supplementary material, table S2). For 23 out of 25 (92%) of the lncRNAs tested, quantitative real-time PCR (qRTPCR) on cDNA templates confirmed the microarray results. Overexpression of BC041455 prevented ERK1/2 phosphorylation. The effects of BC041455 on hormone-dependent MAPK signalling were observed in both MCF-7 and T-47D cells.
pubmed id	28003470
year	2016
title	Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells.
drug	V
circulating	V
survival	V