Detail

Chr	chr16
start	11819829
end	11828845
lncRNA name	BCAR4
entrez id	400500
hgnc id	HGNC:22170
ensg id	ENSG00000262117
refseq id	NR_024049
methods	microarray, qPCR, RNAi etc.
regulated	differential expression
function description	As BCAR4 expression in cell lines did not change the sensitivity to different chemotherapeutic agents, the increased sensitivity to lapatinib is not due to a general mechanism of drug resistance. Also in our BCAR4-expressing cell models, the combination of lapatinib and antioestrogens was more potent in inhibiting cell growth than lapatinib alone; indicating that blocking the ERBB2 pathway with lapatinib re-sensitises BCAR4-expressing cells to antioestrogens. BCAR4 expression strongly sensitised ZR-75-1 and MCF7 breast cancer cells to the combination of lapatinib and antioestrogens.
pubmed id	22892392
year	2012
title	BCAR4 induces antioestrogen resistance but sensitises breast cancer to lapatinib.
drug	V
circulating	X
survival	V