Detail

Chr	chr16
start	52258564
end	52280638
lncRNA name	ENST00000515084
entrez id	NA
hgnc id	HGNC:50627
ensg id	ENSG00000260887
refseq id	NA
methods	qPCR, Luciferase reporter assay, Cell viability assay, Transient transfection etc.
regulated	up-regulated
function description	We found that the C allele of the rs12325489C>T polymorphism in the exonic regions of lincRNA-ENST00000515084 was associated with a significantly increased risk of breast cancer, compared with the rs12325489TT genotype. Biochemical analysis demonstrated that the C to T base change at rs12325489C>T disrupts the binding site for miRNA-370, thereby influencing the transcriptional activity of lincRNA-ENST00000515084 in vitro and in vivo, and affecting cell proliferation and tumor growth.
pubmed id	24879036
year	2014
title	A polymorphism rs12325489C>T in the lincRNA-ENST00000515084 exon was found to modulate breast cancer risk via GWAS-based association analyses.
drug	X
circulating	X
survival	X