Detail

Chr	chr2
start	27392784
end	27393367
lncRNA name	FTH1P3
entrez id	NA
hgnc id	NA
ensg id	ENSG00000213453
refseq id	NA
methods	qPCR,Flow cytometry assay,Western blot,Luciferase reporter assay,etc.
regulated	up-regulated
function description	Bioinformatics tools and luciferase reporter assay validated that,FTH1P3 promoted ABCB1 protein expression through targeting miR-206,acting as,a miRNA sponge. In summary,our results reveal the potential regulatory mechanism ,of FTH1P3 on breast cancer paclitaxel resistance through miR-206/ABCB1,providing a novel insight for the breast cancer chemoresistance. However,the occurrence of chemoresistance causes the poor prognosis,high recurrence rate and low 5-year survival rate.In the present study,we investigate the role of lncRNA FTH1P3 in breast cancer paclitaxel resistance and explore the underlying mechanism for the drug resistance generation.
pubmed id	29971911
year	2018
title	Long non-coding RNA FTH1P3 activates paclitaxel resistance in breast cancer through miR-206/ABCB1.
drug	V
circulating	X
survival	V