Detail

Chr	chr1
start	173863900
end	173868882
lncRNA name	GAS5
entrez id	60674
hgnc id	HGNC:16355
ensg id	ENSG00000234741
refseq id	NR_002578
methods	qRT-PCR, RIP, Luciferase reporter assay, Western blot assay ect.
regulated	down-regulated
function description	GAS5 levels were frequently decreased in breast cancer tissues and cell lines, and its relatively low expression was closely related to a larger tumour size, advanced tumour-node-metastasis (TNM) stage and estrogen receptor-negative (ER-) breast cancer tissues. More importantly, we found that GAS5 promoted autophagy, with enhanced autophagosome formation after GAS5 overexpression. GAS5 was found to act as a microRNA sponge in a pathway that included miR-23a and its target gene ATG3. The GAS5-miR-23a-ATG3 axis significantly regulated autophagy in vivo and in vitro.
pubmed id	30007957
year	2018
title	Effect of the LncRNA GAS5-MiR-23a-ATG3 Axis in Regulating Autophagy in Patients with Breast Cancer.
drug	X
circulating	X
survival	X