Detail

Chr	chr11
start	1995176
end	2001470
lncRNA name	H19
entrez id	283120
hgnc id	HGNC:4713
ensg id	ENSG00000130600
refseq id	NR_002196
methods	qPCR, RNAi, Western blot etc.
regulated	up-regulated
function description	Quantitation of H19 lncRNA in human breast cancer tissues showed that the level of H19 lncRNA was higher in ER-positive than in ER-negative tumor tissues. These results suggest that H19 is an estrogen-inducible gene and plays a key role in cell survival and in estrogen-induced cell proliferation in MCF-7 cells, H19 expression is ER-dependent and induced by estrogen through the traditional genomic pathway of estrogen-ER interaction with the gene.
pubmed id	25846769
year	2015
title	H19 lncRNA mediates 17B-estradiol-induced cell proliferation in MCF-7 breast cancer cells.
drug	X
circulating	X
survival	V