Detail

Chr	chr12
start	53962308
end	53974956
lncRNA name	HOTAIR
entrez id	100124700
hgnc id	HGNC:33510
ensg id	ENSG00000228630
refseq id	NR_003716
methods	qPCR, Western blot, Cell proliferation assay etc.
regulated	down-regulated
function description	Both calycosin and genistein inhibited proliferation and induced apoptosis in MCF-7 breast cancer cells, especially after treatment with calycosin. Treatment of MCF-7 cells with calycosin or genistein resulted in decreased phosphorylation of Akt, and decreased expression of its downstream target, HOTAIR.
pubmed id	25613518
year	2015
title	Calycosin and genistein induce apoptosis by inactivation of HOTAIR/p-Akt signaling pathway in human breast cancer MCF-7 cells.
drug	V
circulating	X
survival	X