Detail

Chr	chr12
start	53962308
end	53974956
lncRNA name	HOTAIR
entrez id	100124700
hgnc id	HGNC:33510
ensg id	ENSG00000228630
refseq id	NR_003716
methods	qPCR, Luciferase reporter assay, Western blot
regulated	up-regulated
function description	HOTAIR was able to up-regulate the expression of Bcl-w in breast cancer cells. miR-206 was capable of inhibiting the expression of Bcl-w by directly binding to the 3'UTR of Bcl-w mRNA.HOTAIR could increase the expression of Bcl-w through sequestering miR-206 at post-transcriptional level. HOTAIR-induced Bcl-w by miR-206 facilitated the proliferation of breast cancer cells.HOTAIR expression in primary breast tumors was significantly associated with worse prognosis independent of prognostic markers.
pubmed id	29222472
year	2017
title	Long Noncoding RNA HOTAIR Modulates MiR-206-mediated Bcl-w Signaling to Facilitate Cell Proliferation in Breast Cancer.
drug	X
circulating	X
survival	V