Detail

Chr	chr7
start	27184518
end	27189293
lncRNA name	HOXA11-AS
entrez id	221883
hgnc id	HGNC:24957
ensg id	ENSG00000240990
refseq id	NR_002795
methods	qPCR etc.
regulated	up-regulated
function description	The data revealed that the relative transcript level of HOXA11-AS was upregulated in vivo and in vitro in models of breast cancer. Knockdown of HOXA11-AS in MDA-MB-231 and MDA-MB-436 breast cancer cell lines inhibited the formation of cell colonies and arrested the cell cycle at the G0/G1 phase. Depletion of HOXA11-AS using two specific short interfering (si)RNAs against HOXA11-AS (siHOXA11-AS-1 and siHOXA11-AS-2) additionally suppressed the cell proliferative rate. Furthermore, transwell assays and wound-healing analysis revealed that siRNA transfection inhibited cell migration and invasion by ~50% in the two cell lines. The results of the present study demonstrated the oncogenic role of HOXA11-AS in breast cancer, providing novel clues for the future clinical diagnosis and treatment of early stage breast cancer patients.
pubmed id	28791375
year	2017
title	Long non-coding RNA HOXA11-AS promotes cell proliferation and metastasis in human breast cancer
drug	X
circulating	X
survival	X