Detail

Chr	NA
start	NA
end	NA
lncRNA name	LINC00894-002
entrez id	NA
hgnc id	NA
ensg id	NA
refseq id	NA
methods	qPCR, Western blot etc.
regulated	down-regulated
function description	LINC00894-002 exhibits the most sophisticated network pattern and is the most downregulated lncRNA in MCF-7/TamR cells. Moreover,LINC00894-002 is directly upregulated by ERa.Knocking down LINC00894-002 downregulates expression of miR-200a-3p and miR-200b-3p, upregulates the expression of TGF-B2 and ZEB1,and finally contributes to TamR.Herein, we report the first case of an inhibitory lncRNA against TamR through the miR-200-TGF-B2-ZEB1 signaling pathway.
pubmed id	29738694
year	2018
title	Downregulation of LINC00894-002 Contributes to Tamoxifen Resistance by Enhancing the TGF-B Signaling Pathway.
drug	X
circulating	X
survival	X