Detail

Chr	chr1
start	238480384
end	238486023
lncRNA name	LINK-A
entrez id	339535
hgnc id	HGNC:27924
ensg id	ENSG00000215808
refseq id	NR_015407
methods	Cell transfection, Fluorescence quenching assay, Lipid-RNA pulldown assay etc.
regulated	differential expression
function description	LINK-A directly interacts with the AKT pleckstrin homology domain and PIP3 at the single-nucleotide level, facilitating AKT-PIP3 interaction and consequent enzymatic activation. LINK-A-dependent AKT hyperactivation leads to tumorigenesis and resistance to AKT inhibitors. Genomic deletions of the LINK-A PIP3-binding motif dramatically sensitized breast cancer cells to AKT inhibitors.
pubmed id	28218907
year	2017
title	The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors.
drug	X
circulating	X
survival	V