Detail

Chr	chr10
start	6737382
end	6739026
lncRNA name	LINP1
entrez id	108570035
hgnc id	HGNC:53170
ensg id	ENSG00000223784
refseq id	NR_138480
methods	qPCR, Western blot
regulated	up-regulated
function description	LINP1 knockdown mitigated breast cancer cell growth by inducing G1-phase cell cycle arrest and apoptosis. LINP1 also promoted breast cancer cell metastasis and influenced the expression of epithelial-mesenchymal transition-related markers. We identified p53 as a regulator of LINP1, and LINP1 overexpression could restore the metastatic effects of p53. Furthermore, LINP1 was upregulated in doxorubicin- and 5-fluorouracil-resistant cells and induced chemoresistance. We also observed that LINP1 enrichment played a critical functional role in chemoresistance by inhibiting chemotherapeutics-induced apoptosis. Moreover, LINP1 in tumors was associated with lower overall survival and disease-free survival.
pubmed id	29293402
year	2018
title	Long noncoding RNA LINP1 acts as an oncogene and promotes chemoresistance in breast cancer.
drug	X
circulating	X
survival	V