Detail

Chr	chr9
start	21455642
end	21559669
lncRNA name	LOC554202
entrez id	554202
hgnc id	HGNC:37187
ensg id	ENSG00000171889
refseq id	NR_027054
methods	qPCR etc.
regulated	down-regulated
function description	Both miR-31 and the host gene LOC554202 are down-regulated in the TNBC cell lines of basal subtype and over-expressed in the luminal counterparts. Treatment of the TNBC cell lines with either a de-methylating agent alone or in combination with a de-acetylating agent resulted in a significant increase of both miR-31 and its host gene, suggesting an epigenetic mechanism for the silencing of these two genes by promoter hypermethylation. Finally, both methylation-specific PCR and sequencing of bisulfite-converted DNA demonstrated that the LOC554202 promoter-associated CpG island is heavily methylated in the TNBC cell lines and hypomethylated in the luminal subtypes.
pubmed id	22289355
year	2012
title	miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer.
drug	X
circulating	X
survival	X