Detail

Chr	chr6
start	10429255
end	10434874
lncRNA name	Linc00518
entrez id	221718
hgnc id	HGNC:28626
ensg id	ENSG00000183674
refseq id	NR_027793
methods	qRT-PCR, Western blot assays, Luciferase reporter assays, RIP
regulated	up-regulated
function description	linc00518 expression increased nearly 2 fold and MRP1 level elevated about 2.5 fold in breast cancer tissues as compared to that in adjacent normal tissues. miR-199a inhibitor conferred chemoresistance to ADR, VCR and PTX in MCF-7/ADR cells, and suppressing miR-199a reversed multi-drug susceptibility induced by linc00518 knockdown. Furthermore, linc00518 could act as a molecular sponge of miR-199a to repress MRP1 expression. MRP1 depletion increased the sensitivity of MCF-7/ADR cells to ADR, VCR and PTX, and this effect was attenuated following miR-199a inhibition or linc00518
pubmed id	30001527
year	2018
title	Linc00518 Contributes to Multidrug Resistance Through Regulating the MiR-199a/MRP1 Axis in Breast Cancer.
drug	V
circulating	X
survival	X