The Genomic Atlas of Breast Cancer — the non-coding theme
| Chr | chr11 |
| start | 65497688 |
| end | 65506516 |
| lncRNA name | MALAT1 |
| entrez id | 378938 |
| hgnc id | HGNC:29665 |
| ensg id | ENSG00000251562 |
| refseq id | NR_002819 |
| methods | qPCR etc. |
| regulated | up-regulated |
| function description | MALAT1 was overexpressed in 14% (63/446) of the breast tumours. MALAT1-overexpressed tumour epithelial cells showed marked diffuse nuclear signals and numerous huge nuclear speckles. Screening of the dbEST database led to the identification of ?¡èsv-MALAT1, a major alternatively spliced MALAT1 transcript, with a very different expression pattern compared with FL-MALAT1. This alternative ?¡èsv-MALAT1 transcript was mainly underexpressed (18.8%) in our breast tumour series. Multivariate analysis showed that alternative ?¡èsv-MALAT1 transcript is an independent prognostic factor. ?¡èsv-MALAT1 expression was associated with alterations of the pre-mRNAs alternative splicing machinery, and of the Drosha-DGCR8 complex required for non-coding RNA biogenesis. |
| pubmed id | 27172249 |
| year | 2016 |
| title | Prognostic value of a newly identified MALAT1 alternatively spliced transcript in breast cancer |
| drug | X |
| circulating | X |
| survival | X |
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