The Genomic Atlas of Breast Cancer — the non-coding theme
| Chr | chr11 |
| start | 65497688 |
| end | 65506516 |
| lncRNA name | MALAT1 |
| entrez id | 378938 |
| hgnc id | HGNC:29665 |
| ensg id | ENSG00000251562 |
| refseq id | NR_002819 |
| methods | qPCR, Luciferase reporter assays etc. |
| regulated | up-regulated |
| function description | MALAT1 inhibition significantly induced cell cycle arrest in the G0/G1 phase. the roles of MALAT1 on TNBC cells progression was mediated by miR-129-5p. the ?¡ăMALAT1-miR-129-5p?¡À axis might play an important role in the progression of TNBC, thereby might provide a potential therapeutic strategy for the treatment of TNBC. patients with high MALAT1 expression had a poor overall survival compared to patients with low MALAT1 expression. |
| pubmed id | 28915533 |
| year | 2017 |
| title | Long non-coding RNA MALAT1 promotes proliferation and invasion via targeting miR-129-5p in triple-negative breast cancer |
| drug | X |
| circulating | X |
| survival | V |
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