Detail

Chr	chr11
start	65497688
end	65506516
lncRNA name	MALAT1
entrez id	378938
hgnc id	HGNC:29665
ensg id	ENSG00000251562
refseq id	NR_002819
methods	qPCR, Luciferase reporter assay, Western blot
regulated	up-regulated
function description	MALAT1 was upregulated in human colon cancer cell lines.miR-129-5p was downregulated in colon cancer cells with a significant increase of HMGB1 expression.miR-129-5p was identified and confirmed as a direct regulator of MALAT1 and miR-129-5p mimics were able to restrain the progression of colon cancer cells. In addition, high motility group box protein 1 (HMGB1), was predicted as a mRNA target of miR-129-5p. MALAT1 may serve as a competing endogenous lncRNA (ceRNA) to mediate HMGB1 by sponging miR-129-5p in colon cancer.
pubmed id	29130936
year	2017
title	JAK2-binding long noncoding RNA promotes breast cancer brain metastasis.
drug	X
circulating	X
survival	X