Detail

Chr	chr17
start	45799390
end	45895630
lncRNA name	MAPT-AS1
entrez id	100128977
hgnc id	HGNC:43738
ensg id	ENSG00000264589
refseq id	NR_024559
methods	qPCR, Western blot, in vitro knockdown
regulated	up-regulated
function description	ER-negative patients with younger age (<60), larger tumors (??2cm), metastatic lymph nodes and stages (III-IV) had higher expression of MAPT-AS1. MAPT-AS1 is correlated with the cell growth, invasiveness and paclitaxel resistance by regulating its natural comparable sense transcripts MAPT in ER-negative breast cancer cells. The result revealed that MAPT-AS1 overexpression could partially protect the MAPT mRNA from degradation, while MAPT-AS1 knockdown decreased the stability of MAPT mRNA. Meanwhile, MAPT knockdown decreased the expression of MAPT-AS1 mRNA. MAPT-AS1 expressed coordinately with MAPT in breast tumor tissues.
pubmed id	29441192
year	2018
title	Knockdown of LncRNA MAPT-AS1 inhibites proliferation and migration and sensitizes cancer cells to paclitaxel by regulating MAPT expression in ER-negative breast cancers.
drug	X
circulating	X
survival	X