Detail

Chr	chr14
start	100779410
end	100861031
lncRNA name	MEG3
entrez id	55384
hgnc id	HGNC:14575
ensg id	ENSG00000214548
refseq id	NR_002766
methods	qPCR, Western blot etc.
regulated	down-regulated
function description	MEG3 was significantly down-regulated in breast cancer tissues compared to adjacent normal tissues.MEG3/miR-421/E-cadherin regulatory axis may be a novel therapeutic target for breast cancer.endogenous miR-421 expression was negatively regulated by MEG3 in breast cancer cells and MEG3 regulated E-cadherin expression by sponging to miR-421 in breast cancer cells.Survival analysis showed that lower MEG3 predicted a poor DFS and OS for patients. Down-regulation of MEG3 enhances cisplatin resistance of lung cancer cells through activation of the WNT/b-catenin signaling pathway.
pubmed id	28463794
year	2017
title	LncRNA MEG3 inhibits cell epithelial-mesenchymal transition by sponging miR-421 targeting E-cadherin in breast cancer.
drug	V
circulating	X
survival	V