Detail

Chr	chr22
start	26646428
end	26676475
lncRNA name	MIAT
entrez id	440823
hgnc id	HGNC:33425
ensg id	ENSG00000225783
refseq id	NR_003491
methods	qPCR, Western blot, Luciferase report assay etc.
regulated	up-regulated
function description	MIAT expression was upregulated in breast cancer cell lines and tissues.MIAT acted as a competing endogenous RNA (ceRNA) to regulate the expression of dual specificity phosphatase 7 (DUSP7) by taking up miR-155-5p in breast cancer. There were positive correlation between MIAT and DUSP7 expression in breast cancer patients.MIAT promotes breast cancer progression and functions as ceRNA to regulate DUSP7 expression by sponging miR-155-5p in breast cancer. MIAT was specifically up-regulated in the plasma and aqueous humor of cataract patients.
pubmed id	29100300
year	2017
title	Long non-coding RNA MIAT promotes breast cancer progression and functions as ceRNA to regulate DUSP7 expression by sponging miR-155-5p.
drug	X
circulating	X
survival	X