Detail

Chr	chr11
start	65422774
end	65445540
lncRNA name	NEAT1
entrez id	283131
hgnc id	HGNC:30815
ensg id	ENSG00000245532
refseq id	NR_028272
methods	qPCR, RNAi, ChIP etc.
regulated	up-regulated
function description	Our studies show that NEAT1 upregulation resulting from BRCA1 deficiency stimulates in vitro and in vivo breast tumorigenicity. NEAT1 epigenetically silences miR-129-5p expression by promoting the DNA methylation of the CpG island in the miR-129 gene. Silencing of miR-129-5p expression by NEAT1 results in upregulation of WNT4 expression, a target of miR-129-5p, which leads to activation of oncogenic WNT signaling. Our functional studies indicate that this NEAT1/miR-129-5p/WNT4 axis contributes to the tumorigenic effects of BRCA1 deficiency. Finally our in silico expression correlation analysis suggests the existence of the BRCA1/NEAT1/miR-129-5p axis in breast cancer.
pubmed id	27556296
year	2016
title	Dysregulation of the BRCA1/long non-coding RNA NEAT1 signaling axis contributes to breast tumorigenesis.
drug	X
circulating	X
survival	X