Detail

Chr	chr11
start	65422774
end	65445540
lncRNA name	NEAT1
entrez id	283131
hgnc id	HGNC:30815
ensg id	ENSG00000245532
refseq id	NR_028272
methods	qPCR, Luciferase reporter assay, Western blot
regulated	up-regulated
function description	lncRNA NEAT1 was up-regulated in breast cancer cell lines and tissues.NEAT1 promoted invasion through inducing Epithelial-mesenchymal transition (EMT) and NEAT1 played a role in 5-fluorouracil (5-FU) resistance.the EMT-inducer HMGA2 was identified as a down-stream target of miR-211.LncRNA NEAT1 induced EMT and 5-FU resistance through the miR-211/HMGA2 axis.breast cancer patients with low levels of NEAT1 expression had better overall survival time than those with high levels.
pubmed id	28720546
year	2017
title	The lncRNA NEAT1 facilitates cell growth and invasion via the miR-211/HMGA2 axis in breast cancer.
drug	X
circulating	X
survival	V