Detail

Chr	chr11
start	65422774
end	65445540
lncRNA name	NEAT1
entrez id	283131
hgnc id	HGNC:30815
ensg id	ENSG00000245532
refseq id	NR_028272
methods	qRT-PCR, Western blot, Luciferase reporter assay, in vitro knockdown
regulated	up-regulated
function description	NEAT1 levels were significantly increased in human breast cancer cells including MCF-7, MDA-MB-453, MDA-MB-231, and SKBR3 cells compared to normal mammary epithelial cells MCF-10A while miR-448 was decreased. We found that downregulation of NEAT1 was able to inhibit the growth of breast cancer cells and miR-448 mimic exerted the similar function. Bioinformatics analysis and dual luciferase reporter assays confirmed the negative correlation between NEAT1 and miR-448 in vitro. It was speculated in our study that NEAT1 can serve as a competing endogenous lncRNA (ceRNA) to modulate ZEB1 by sponging miR-448 in breast cancer.
pubmed id	29323713
year	2018
title	NEAT1 contributes to breast cancer progression through modulating miR-448 and ZEB1.
drug	X
circulating	X
survival	X