Detail

Chr	chr6
start	36673621
end	36675126
lncRNA name	PANDAR
entrez id	101154753
hgnc id	HGNC:44048
ensg id	ENSG00000281450
refseq id	NR_109836
methods	qPCR, Western blot, RIP, ChIP, Luciferase reporter assay etc.
regulated	up-regulated
function description	we investigated the role of lncRNA PANDAR in the progression of breast cancer and found that PANDAR was up-regulated in breast cancer tissues and cell lines. The knockdown of PANDAR suppresses G1/S transition of breast cancer cells. We demonstrated mechanistically that the regulation of G1/S transition by PANDAR was partly due to the transcriptional modulation of p16INK4A. Moreover, we showed that PANDAR impacted p16INK4A expression by regulating the recruitment Bmi1 to p16INK4A promoter
pubmed id	26927017
year	2016
title	LncRNA PANDAR regulates the G1/S transition of breast cancer cells by suppressing p16(INK4A) expression
drug	X
circulating	X
survival	X