The Genomic Atlas of Breast Cancer — the non-coding theme
| Chr | NA |
| start | NA |
| end | NA |
| lncRNA name | PICART1 |
| entrez id | NA |
| hgnc id | NA |
| ensg id | NA |
| refseq id | NA |
| methods | qPCR, Cell transfection, Western blot, Cell proliferation assay etc. |
| regulated | down-regulated |
| function description | In breast and colorectal cancer cells and tissues, PICART1 expression was found to be decreased. Ectopic expression of PICART1 suppressed the growth, proliferation, migration, and invasion of MCF7, MDA-MB-231 and HCT116 cells whereas silencing of PICART1 stimulated cell growth and migration. In these cells, the expression of PICART1 suppressed levels of p-AKT (Thr308 and Ser473) and p-GSK3B (Ser9), and accordingly, B-catenin, cyclin D1 and c-Myc expression were decreased, while p21Waf/cip1 expression was increased. |
| pubmed id | 28339031 |
| year | 2017 |
| title | p53-inducible long non-coding RNA PICART1 mediates cancer cell proliferation and migration. |
| drug | X |
| circulating | X |
| survival | X |
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