The Genomic Atlas of Breast Cancer — the non-coding theme
| Chr | chr8 |
| start | 127794533 |
| end | 128101253 |
| lncRNA name | PVT1 |
| entrez id | 5820 |
| hgnc id | HGNC:9709 |
| ensg id | ENSG00000249859 |
| refseq id | NR_003367 |
| methods | qPCR etc. |
| regulated | up-regulated |
| function description | These results suggest that MYC and PVT1 contribute independently to ovarian and breast pathogenesis when overexpressed because of genomic abnormalities. They also suggest that PVT1-mediated inhibition of apoptosis may explain why amplification of 8q24 is associated with reduced survival duration in patients treated with agents that act through apoptotic mechanisms. |
| pubmed id | 17908964 |
| year | 2007 |
| title | Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. |
| drug | X |
| circulating | X |
| survival | V |
CopyRight © University of Miami, USA; Harbin Medical University, China
