Detail

Chr	chr8
start	127794533
end	128101253
lncRNA name	PVT1
entrez id	5820
hgnc id	HGNC:9709
ensg id	ENSG00000249859
refseq id	NR_003367
methods	qPCR, Western blot etc.
regulated	down-regulated
function description	To achieve cognition into the biological functions of PVT1 on breast cancer, PVT1 expression was downregulated by transfecting PVT1 siRNA into the MCF-7 and MDA-MB-231 cells, employing the scramble siRNA as a negative control.PVT1 DNA in serum and found that circulating PVT1 DNA significantly increased in the serum of breast cancer patients. circulating PVT1 DNA fragments may be a convenient means to predict the prognosis of breast cancer patients.The results demonstrated that breast cancer patients with high PVT1 expression showed significant shorter 5-year overall survival (OS) compared with patients with low PVT1 expression.
pubmed id	28534994
year	2017
title	Amplification and the clinical significance of circulating cell-free DNA of PVT1 in breast cancer.
drug	X
circulating	V
survival	V