Detail

Chr	chr21
start	36131767
end	36175815
lncRNA name	PlncRNA-1
entrez id	100506428
hgnc id	HGNC:43664
ensg id	ENSG00000236830
refseq id	NR_038892
methods	qPCR, Western blot etc.
regulated	down-regulated
function description	Expression levels of PlncRNA-1 were significantly lower in tumor tissues than those in adjacent healthy tissues. Significantly lower expression levels of PlncRNA-1 were also found in breast cancer patients than those in healthy controls in both breast tissue and serum. Upregulation of PlncRNA-1 promoted the expression of TGF-B1, but inhibited the expression of PHGDH. LncRNA PlncRNA-1 overexpression reduced the proliferation rate, but increased the apoptosis rate of breast cancer cells, while treatment with TGF-B inhibitor reduced those effects of PlncRNA-1 overexpression.
pubmed id	29626321
year	2018
title	LncRNA PlncRNA-1 overexpression inhibits the growth of breast cancer by upregulating TGF-B1 and downregulating PHGDH.
drug	X
circulating	V
survival	X