Detail

Chr	chr17
start	76557766
end	76565348
lncRNA name	SNHG16
entrez id	100507246
hgnc id	HGNC:44352
ensg id	ENSG00000163597
refseq id	NR_038108
methods	qPCR, RNAi, Western blot, RIP, Luciferase reporter assay etc.
regulated	up-regulated
function description	Expression levels of SNHG16 were found to be frequently higher in breast cancer tissues than in the paired noncancerous tissues.Gain- and loss-of-function studies proved that SNHG16 significantly promoted breast cancer cell migration. In addition, we identified a positive correlation between SNHG16 and E2F5 in breast cancer tissues. Furthermore,we demonstrated that forced expression of miR-98 could partially abrogate SNHG16-mediated increase of breast cancer cells migration,suggesting that SNHG16 promoted cell migration in a miR-98 dependent manner.
pubmed id	28232182
year	2017
title	SNHG16 contributes to breast cancer cell migration by competitively binding miR-98 with E2F5.
drug	X
circulating	X
survival	X