Detail

Chr	chr5
start	140537340
end	140558252
lncRNA name	SRA1
entrez id	NA
hgnc id	NA
ensg id	ENSG00000213523
refseq id	NA
methods	qPCR, Western blot etc.
regulated	up-regulated
function description	We report a significant higher SRA-intron-1 relative expression in breast tumors with higher progesterone receptor contents. Using an antisense oligoribonucleotide, we have successfully reprogrammed endogenous SRA splicing and increased SRA RNA-intron-1 relative level in T5 breast cancer cells. Our results suggest that the balance coding/non-coding SRA transcripts not only characterizes particular tumor phenotypes but might also, through regulating the expression of specific genes, be involved in breast tumorigenesis and tumor progression.
pubmed id	19483093
year	2009
title	Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides.
drug	X
circulating	X
survival	X