Detail

Chr	chr1
start	3735601
end	3747336
lncRNA name	TP73-AS1
entrez id	57212
hgnc id	HGNC:29052
ensg id	ENSG00000227372
refseq id	NR_033708
methods	qPCR, Luciferase reporter assay, Western blot
regulated	up-regulated
function description	TP73-AS1 was specifically upregulated in BC tissues and BC cell lines and was correlated to a poorer prognosis in patients with BC. TP73-AS1 could regulate miR-200a through direct targeting. Moreover, TP73-AS1 might compete with TFAM for miR-200a binding thus to promote TFAM expression.TP73-AS1 promoted BC cell proliferation through acting as a competing endogenous RNA (ceRNA) by sponging miR-200a. High TP73-AS1 expression in BC was related with poorer clinicopathological parameters and shorter overall survival.
pubmed id	28639399
year	2017
title	TP73-AS1 promotes breast cancer cell proliferation through miR-200a-mediated TFAM inhibition.
drug	X
circulating	X
survival	V