Detail

Chr	chr19
start	15828206
end	15836326
lncRNA name	UCA1
entrez id	652995
hgnc id	HGNC:37126
ensg id	ENSG00000214049
refseq id	NR_015379
methods	qPCR etc.
regulated	up-regulated
function description	We found that treatment with macrophage CM induced the expression of numerous lncRNAs, including urothelial cancer associated 1 (UCA1). Knockdown of UCA1 using shRNA inhibited AKT phosphorylation and abolished invasiveness of tumor cells induced by macrophage CM. Consistent with these results; we further showed that UCA1 level was significantly enhanced in human primary breast tumors and correlated with advanced clinical stage, supporting its role in promoting carcinogenesis and progression of breast cancer
pubmed id	26464647
year	2015
title	Macrophage infiltration promotes invasiveness of breast cancer cells via activating long non-coding RNA UCA1
drug	X
circulating	X
survival	X