Detail

Chr	chr19
start	15828206
end	15836326
lncRNA name	UCA1
entrez id	652995
hgnc id	HGNC:37126
ensg id	ENSG00000214049
refseq id	NR_015379
methods	Western blot, Cell invasion assay etc.
regulated	differential expression
function description	Knockdown of endogenous UCA1 significantly reduced the number of invading cells. MDA-MB-231 cells with UCA1 knockdown had significantly increased expression of E-cadherin but decreased expression of N-cadherin, Vimentin and Snail. UCA1 inhibition substantially increased the expression of p-GSK-3B and GSK-3B and suppressed the protein expression of B-catenin and transcription of the downstream genes, including cyclin D1 and MMP-7.
pubmed id	27424981
year	2016
title	LncRNA UCA1 promotes epithelial-mesenchymal transition (EMT) of breast cancer cells via enhancing Wnt/beta-catenin signaling pathway.
drug	X
circulating	X
survival	X