Detail

Chr	chr19
start	15828206
end	15836326
lncRNA name	UCA1
entrez id	652995
hgnc id	HGNC:37126
ensg id	ENSG00000214049
refseq id	NR_015379
methods	qPCR, Western blot, Dual-luciferase reporter assay, Flow cytometry assay etc.
regulated	up-regulated
function description	Our findings reveal that tamoxifen induces UCA1 upregulation in ER-positive breast cancer cells in a HIF1a-dependent manner. UCA1 upregulation results in significantly enhanced tamoxifen resistance. The upregulated UCA1 sponges miR-18a, which is a negative regulator of HIF1a. Therefore, UCA1 upregulation is further enhanced through a miR-18a-HIF1a feedback loop.
pubmed id	27629141
year	2016
title	Long non-coding RNA UCA1 enhances tamoxifen resistance in breast cancer cells through a miR-18a-HIF1a feedback regulatory loop.
drug	V
circulating	X
survival	X