The Genomic Atlas of Breast Cancer — the non-coding theme
| Chr | chr19 |
| start | 15828206 |
| end | 15836326 |
| lncRNA name | UCA1 |
| entrez id | 652995 |
| hgnc id | HGNC:37126 |
| ensg id | ENSG00000214049 |
| refseq id | NR_015379 |
| methods | Microarray, qPCR, RIP, Luciferase reporter assay etc. |
| regulated | up-regulated |
| function description | We observed that TGF-B induced genome-wide changes in lncRNA levels in breast cancer cells, among which AC026904.1 and UCA1 were highly expressed in metastatic breast cancer and closely associated with poor prognosis. UCA1 exerts a competitive endogenous RNA (ceRNA) activity in the cytoplasm. |
| pubmed id | 29774079 |
| year | 2018 |
| title | Long non-coding RNAs AC026904.1 and UCA1: a ?¡ãone-two punch?¡À for TGF-B-induced SNAI2 activation and epithelial-mesenchymal transition in breast cancer |
| drug | X |
| circulating | X |
| survival | V |
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