Detail

Chr	chrX
start	73820651
end	73852753
lncRNA name	XIST
entrez id	7503
hgnc id	HGNC:12810
ensg id	ENSG00000229807
refseq id	NR_001564
methods	qPCR, Cell cycle assay etc.
regulated	down-regulated
function description	Using gene expression profiling, we identified the long noncoding RNA Xist (X-inactive specific transcript) as a biomarker predicting BCL response to HDACi. We validated that low Xist expression predicts drug response in PDXs associated with a significant reduction of the breast CSC population.
pubmed id	24141629
year	2013
title	The histone deacetylase inhibitor abexinostat induces cancer stem cells differentiation in breast cancer with low Xist expression.
drug	V
circulating	X
survival	X