Detail

Chr	chr18
start	57054558
end	57072119
lncRNA name	linc-ROR
entrez id	100885779
hgnc id	HGNC:43773
ensg id	ENSG00000258609
refseq id	NR_048536
methods	qPCR, RIP, in vivo knockdown etc.
regulated	up-regulated
function description	linc-ROR was upregulated in breast tumor and ectopic overexpression of linc-ROR in immortalized human mammary epithelial cells induced an epithelial-to-mesenchymal transition (EMT) program. Moreover,linc-ROR enhanced breast cancer cell migration and invasion. Linc-ROR was associated with miRNPs and functioned as a competing endogenous RNA to mi-205. linc-ROR functions as an important regulator of EMT and can promote breast cancer progression and metastasis through regulation of miRNAs.
pubmed id	24922071
year	2014
title	LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis.
drug	X
circulating	X
survival	X