Detail

Chr	chr18
start	57054558
end	57072119
lncRNA name	linc-ROR
entrez id	100885779
hgnc id	HGNC:43773
ensg id	ENSG00000258609
refseq id	NR_048536
methods	qPCR, RNAi, Western blot, ChIP, Flow cytometry assay etc.
regulated	up-regulated
function description	Untreated MDA-MB-231 cell lines strongly expressed linc-ROR, but linc-ROR knockdown decreased cell viability and expression of p62 and p53 while increasing apoptosis. Linc-ROR knockdown also increased LC3-II/B-actin, Beclin 1, NOTCH1, and Bcl-2 expression, as well as the number of autophagic vesicles in MDA-MB-231 cells. Linc-ROR negatively regulated miR-34a expression by inhibiting histone H3 acetylation in the miR-34a promoter.
pubmed id	27449099
year	2016
title	Large intergenic non-coding RNA-ROR reverses gemcitabine-induced autophagy and apoptosis in breast cancer cells.
drug	X
circulating	X
survival	X