Detail

Chr	NA
start	NA
end	NA
lncRNA name	lincRNA-p21
entrez id	102800311
hgnc id	HGNC:43652
ensg id	NA
refseq id	NA
methods	qPCR, Western blot, RIP, ISH, MTT assay etc.
regulated	up-regulated
function description	We found that Linc-RoR was highly expressed in tumor specimens compared to normal tissue. Linc-RoR knockout (KO) suppresses cell proliferation and tumor growth. In particular, Linc-RoR KO causes a significant decrease in c-Myc whereas re-expression of Linc-RoR in the KO cells restores the level of c-Myc. As a result, Linc-RoR may contribute to the increased stability of c-Myc mRNA. Although hnRNP I and AUF1 can interact with many RNA species and regulate their functions, with involvement of Linc-RoR they would be able to selectively regulate mRNA stability of specific genes such as c-Myc.
pubmed id	26656491
year	2016
title	Linc-RoR promotes c-Myc expression through hnRNP I and AUF1.
drug	X
circulating	X
survival	X