Detail

Chr	NA
start	NA
end	NA
lncRNA name	lncRNA-ATB
entrez id	109207222
hgnc id	NA
ensg id	NA
refseq id	NA
methods	microarray, qPCR, Western blot, Luciferase reporter assay, MTT assay etc.
regulated	up-regulated
function description	We identified long noncoding RNA activated by TGF-B (lnc-ATB) was the most remarkably upregulated lncRNA in TR SKBR-3 cells and the tissues of TR breast cancer patients. We found that lnc-ATB could promote trastuzumab resistance and invasion-metastasis cascade in breast cancer by competitively biding miR-200c, up-regulating ZEB1 and ZNF-217, and then inducing EMT. In addition, we also found that the high level of lnc-ATB was correlated with trastuzumab resistance of breast cancer patients.
pubmed id	25871474
year	2015
title	LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer.
drug	V
circulating	X
survival	X