chr	Start	end	start	gengsymbol	circRNA name	methods	regulated	function description	pubmed id	year	title	drug	circulating	survival	index
NA	NA	NA	NA	NA	circ_0001667	luciferase assay,qRT-PCR,Western blot,etc.	up	This study uncovered that circ_0001667 was a potential breast cancer prognostic marker, as well as a potential therapeutic target to inhibit breast cancer metastasis by circ_0001667/miR-125a-5p/TAZ axis.	31893023	2019	Circ_0001667 promotes breast cancer cell proliferation and survival via Hippo signal pathway by regulating TAZ.	0	0	0	1
NA	NA	NA	NA	NA	circ_0008039	etc.	up	ncRNAs are dysregulated in breast cancer and miRNAs, noted for their stability, and lncRNAs arebeing investigated as biomarkers of disease pathology, prognostic indicators, and potential therapeutictargets, as well as modalities to block cancer progression and metastasis. We know much moreabout miRNAs than lncRNAs in human breast tumors. Our understanding of the networks betweenmiRNAs, lncRNAs, their interacting partners, and targets is expanding. However, individual andcombinations of miRNAs and lncRNAs have cell-specific activities that are not fully understood,nor is their interaction with the immune system, microbiome, microenvironment, hormonal milieu,or metabolome elucidated. Further investigation is needed to bring studies on miRNAs and lncRNAsinto clinical practice for diagnosis, prognosis, and therapeutics in breast cancer patients	30545127	2018	Non-Coding RNAs in Breast Cancer: Intracellular and Intercellular Communication.	0	0	0	2
NA	NA	NA	NA	NA	circ_0006528	qRT-PCR,microarray,Western blot,etc.	Down?	In conclusion, our present study analyzed the expression of circRNAs in chemoresistant breast cancer; we revealedthat circRNAs may play a role in breast cancer chemoresistance, andcirc0006528might be a worthy candidatefor further verification and functional analysis.	28803498	2017	Screening Circular RNA Related to Chemotherapeutic Resistance in Breast Cancer	0	0	0	3
NA	NA	NA	NA	NA	circ_000911	qRT-PCR,luciferase assay,RIP,Western blot,etc.	down	In conclusion, in this study, and to the best of our knowledge, we report for the first time that circRNA?000911 plays an anti?oncogenic role in breast cancer. Moreover, circRNA-000911 exerts its function by serving as a miRNA sponge for miR-449a and thereby promoting the function of Notch1 and the NF-B signaling pathway. Therefore, circRNA-000911 may serve as a promising predictive biomarker and therapeutic target for patients with breast cancer.	29431182	2018	Comprehensive Circular RNA Profiling Reveals the Regulatory Role of the circRNA-000911/miR-449a Pathway in Breast Carcinogenesis	0	0	0	4
NA	NA	NA	NA	NA	circABCB10	qRT-PCR,Luciferase assay,etc.	Down	The differences in circRNA expression in breast cancer tissue are associated with diverse pathogenesis. The present study identified circ-ABCB10 in breast cancer tissue, and its role in acting as a miR-1271 sponge. In summary, the role of circ-ABCB10 in breast cancer carcino-genesis via sponging miR-1271 provides a novel insight for therapy and prevention in breast cancer	28744405	2017	Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271. 	0	0	0	5
NA	NA	NA	NA	NA	circABCB10 	etc.	up	ncRNAs are dysregulated in breast cancer and miRNAs, noted for their stability, and lncRNAs arebeing investigated as biomarkers of disease pathology, prognostic indicators, and potential therapeutictargets, as well as modalities to block cancer progression and metastasis. We know much moreabout miRNAs than lncRNAs in human breast tumors. Our understanding of the networks betweenmiRNAs, lncRNAs, their interacting partners, and targets is expanding. However, individual andcombinations of miRNAs and lncRNAs have cell-specific activities that are not fully understood,nor is their interaction with the immune system, microbiome, microenvironment, hormonal milieu,or metabolome elucidated. Further investigation is needed to bring studies on miRNAs and lncRNAsinto clinical practice for diagnosis, prognosis, and therapeutics in breast cancer patients	30545127	2018	Non-Coding RNAs in Breast Cancer: Intracellular and Intercellular Communication.	0	0	0	6
NA	NA	NA	NA	NA	circACAP2	qRT-PCR,Luciferase assay,RIP,etc.	up	Conclusion:Elevated expression of circACAP2in breast cancer tissues leads to malignant phenotype upon cancerous cells. CircACAP2-miR-29a/b-3p-COL5A1 axis leads to breast cancertumorigenesis andcouldhopefullybe a novel method for diagnosis and treatment for breast cancer.	31863774	2020	CircACAP2 promotes breast cancer proliferation and metastasis by targeting miR-29a/b-3p-COL5A1 axis.	0	0	0	7
NA	NA	NA	NA	NA	circAGFG1	qRT-PCR,microarray,FISH,luciferase assay,Western blot,etc.	up	Results:We found that circAGFG1 was evidently up-regulated in TNBC, and its level was correlated with clinicalstage, pathological grade and poor prognosis of patients with TNBC. The results indicated that circAGFG1 couldpromote TNBC cell proliferation, mobility and invasion as well as tumorigenesis and metastasis in vivo.Mechanistic analysis showed that circAGFG1 may act asa ceRNA (competing endogenous RNA) of miR-195-5p torelieve the repressive effect of miR-195-5p on its target cyclin E1 (CCNE1).Conclusions:Our findings suggest that circAGFG1 promotes TNBC progression through circAGFG1/miR-195-5p/CCNE1 axis and it may serve as a new diagnostic marker or target for treatment of TNBC patients.	30621700	2019	The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression.	1	0	1	8
NA	NA	NA	NA	NA	circAGFG1	qRT-PCR,microarray,FISH,luciferase assay,Western blot,RIP,etc.	Down?	Results:We found that circAGFG1 was evidently up-regulated in TNBC, and its level was correlated with clinicalstage, pathological grade and poor prognosis of patients with TNBC. The results indicated that circAGFG1 couldpromote TNBC cell proliferation, mobility and invasion as well as tumorigenesis and metastasis in vivo.Mechanistic analysis showed that circAGFG1 may act asa ceRNA (competing endogenous RNA) of miR-195-5p torelieve the repressive effect of miR-195-5p on its target cyclin E1 (CCNE1).Conclusions:Our findings suggest that circAGFG1 promotes TNBC progression through circAGFG1/miR-195-5p/CCNE1 axis and it may serve as a new diagnostic marker or target for treatment of TNBC patients.	30621700	2019	The circRNA cir-cAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression. 	0	0	1	9
NA	NA	NA	NA	NA	circAHNAK1	qRT-PCR,Western blot,Luciferase assay,etc.	Down?	In conclusion, circAHNAK1 is down-regulated in TNBC and its expression is negatively correlated with survival outcome in patients with TNBC. circAHNAK1 regulates TNBC cell proliferation and invasion, and the mechanism may be related to the expression of the tumor suppressor gene RASA1 by sponge miR-421, thereby promoting the progression of TNBC. The circAHNAK1-miR-421-RASA1 axis participates in TNBC progression through a competitive ceRNA mechanism. Therefore, circAHNAK1 can be used as a predictor of TNBC prognosis and a potential molecular target.	31857500	2019	CircAHNAK1 inhibits proliferation and metastasis of triple-negative breast cancer by modulating miR-421 and RASA1.	0	0	1	10
NA	NA	NA	NA	NA	circANKS1B	Luciferase assay,RNAi,qRT-PCR,etc.	differential expression	Results:CircANKS1B was significantly up-regulated in triple-negative breast cancer (TNBC) compared with non-TNBCtissues and cell lines. Increased circANKS1B expression was closely associated with lymph node metastasis andadvanced clinical stage and served as an independent risk factor for overall survival of breast cancer patients.Functional studies revealed that circANKS1B promoted breast cancer invasion and metastasis both in vitro andin vivo by inducing epithelial-to-mesenchymal transition (EMT), while had no effect on breast cancer growth.Mechanistically, circANKS1B abundantly sponged miR-148a-3p and miR-152-3p to increase the expression oftranscription factor USF1, which could transcriptionally up-regulate TGF-1 expression, resulting in activatingTGF-1/Smad signaling to promote EMT. Moreover, we found that circANKS1B biogenesis in breast cancerwas promoted by splicing factor ESRP1, whose expression was also regulated by USF1.Conclusions:Our data uncover an essential role of the novel circular RNA circANKS1B in the metastasis ofbreast cancer, which demonstrate that therapeutic targeting of circANKS1B may better prevent breast cancermetastasis	30454010	2018	The pro-metastasis effect of circANKS1B in breast cancer.	0	0	1	11
NA	NA	NA	NA	NA	circANKS1B	qRT-PCR,RNAi,Luciferase assay,etc.	Up	Results:CircANKS1B was significantly up-regulated in triple-negative breast cancer (TNBC) compared with non-TNBCtissues and cell lines. Increased circANKS1B expression was closely associated with lymph node metastasis andadvanced clinical stage and served as an independent risk factor for overall survival of breast cancer patients.Functional studies revealed that circANKS1B promoted breast cancer invasion and metastasis both in vitro andin vivo by inducing epithelial-to-mesenchymal transition (EMT), while had no effect on breast cancer growth.Mechanistically, circANKS1B abundantly sponged miR-148a-3p and miR-152-3p to increase the expression oftranscription factor USF1, which could transcriptionally up-regulate TGF-1 expression, resulting in activatingTGF-1/Smad signaling to promote EMT. Moreover, we found that circANKS1B biogenesis in breast cancerwas promoted by splicing factor ESRP1, whose expression was also regulated by USF1.Conclusions:Our data uncover an essential role of the novel circular RNA circANKS1B in the metastasis ofbreast cancer, which demonstrate that therapeutic targeting of circANKS1B may better prevent breast cancermetastasis	30454010	2018	The pro-metastasis effect of cir-cANKS1B in breast cancer.	0	0	1	12
NA	NA	NA	NA	NA	circASS1	qRT-PCR,luciferase assay,Western Blot,etc.	down	In summary, our study suggests that circASS1 expression is significantly down-regulated in highly aggressive BCcells and circASS1 suppresses invasion and migration of BC by the sponge activity on miR-4443 and upregulationof ASS1 expression, implying its tumor suppressive role in BC development. The regulation of circASS1in vitroindicates that it may be a potential targeted therapy in BC	30657346	2019	Circular RNA circASS1 Is Downregulated in Breast Cancer Cells MDA-MB-231 and Suppressed Invasion and Migration	0	0	0	13
NA	NA	NA	NA	NA	circASS1	qRT-PCR,luciferase assay,Western Blot,etc.	Down?	Results: CircASS1 in MDA-MB-231 is downregulated comparing to MCF-7, and overexpression of circASS1 could suppress invasion and migration. While silence, it could promote invasion and migration. MiR-4443 functioning as a tumor promoter gene could be captured by circASS1. ASS1 is upregulated in loss-of-function experiments, while downregulated in gain-of-function experiments.Conclusion: CircASS1 suppresses invasion and migration capacity of breast cancer cells and harbored miR-4443. 	30657346	2019	Circular RNA circASS1 is downregulated in breast cancer cells MDA-MB-231 and suppressed invasion and migration.	0	0	0	14
NA	NA	NA	NA	NA	circCcnb1	microarray,etc.	Down?	To explore the possibility of using circ-Ccnb1 as anagent for cancer therapy, we developed a peritoneal cancermodel by injecting cancer cells into the peritoneal cavity ofmice. This way, the tumor cells can readily spread every-where in the cavity forming a large number of small tumors.This approach mimics a number of cancers such as serousovarian carcinoma and lung cancer. It allows easy uptake ofnanoparticle conjugated circ-Ccnb1 expression plasmids.For large solid tumors, the efficiencies of plasmid uptakeare significantly lower than these small tumors. Advancedtechniques need to be developed to allow effective deliveryof plasmids, such as circ-Ccnb1, into solid tumors for futurecancer therapy.	29795334	2018	Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1.	0	0	1	15
NA	NA	NA	NA	NA	circCDYL 	luciferase assay,qRT-PCR,etc.	up	Results:An autophagy associated circRNA circCDYL was elevated by 3.2 folds in BC tissues as compared with theadjacent non-cancerous tissues, and circCDYL promoted autophagic level in BC cells via the miR-1275-ATG7/ULK1axis; Moreover, circCDYL enhanced the malignant progression of BC cells in vitro and in vivo. Clinically, increasedcircCDYL in the tumor tissues and serum of BC patients was associated with higher tumor burden, shorter survivaland poorer clinical response to therapy.Conclusions:circCDYL promotes BC progression via the miR-1275-ATG7/ULK1-autophagic axis and circCDYL couldact as a potential prognostic and predictive molecule for breast cancer patients	32213200	2020	Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression.	0	0	1	16
NA	NA	NA	NA	NA	circDENND4C	qRT-PCR,Western blot,RIP,etc.	up	Results:circDENND4C highly expressed in breast cancer was up-regulated in response to hypoxia. Knockdown ofcircDENND4C decreased glycolysis, migration and invasion in breast cancer cells under hypoxia. circDENND4C wasvalidated as a sponge of miR-200b and miR-200c. Deficiency of miR-200b or miR-200c reversed the suppressiveeffect of circDENND4C knockdown on breast cancer progression. Moreover, silence of circDENND4C reducedxenograft tumor growth by increasing miR-200b and miR-200c.Conclusion:circDENND4C silence suppresses glycolysis, migration and invasion in breast cancer cells underhypoxia by increasing miR-200b and miR-200c.	31488193	2019	Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia.	0	0	1	17
NA	NA	NA	NA	NA	circDENND4C	Western blots,etc.	up	Results: In breast cancer cells, circDENND4C was increased under hypoxic conditions and decreased after knocking-down HIF1. In addition, knocking-down circDENND4C inhibited proliferation of breast cancer cells in a hypoxic environment. Finally, tumors with a large size had higher circDENND4C expression levels than those of small size.Conclusion: CircDENND4C is a HIF1-associated circRNA promoting the proliferation of breast cancer cells under hypoxia. 	28739726	2017	HIF1-associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment.	0	0	0	18
NA	NA	NA	NA	NA	circDNMT1	etc.	up	thus anticipated that circular RNAs could impact geneexpression using a separate mechanism from mRNAs ofthe same origin. The emergence of circular RNAs expres-sed by mammalian cells may shed further light on under-standing gene expression, with relevance toward variousbiological paradig	29973691	2018	A circular RNA circ-DNMT1 enhances breast cancer progression by activating autophagy.	0	0	1	19
NA	NA	NA	NA	NA	circEPSTI1	Microarray,qRT-PCR,Luciferase assay,Western blot,etc.	differential expression	Results: Knockdown of circEPSTI1 inhibits TNBC cell proliferation and induces apoptosis. In vitroand in vivo experiments indicated that circEPSTI1 binds to miR-4753 and miR-6809 as a miRNA sponge to regulate BCL11A expression and affect TNBC proliferation and apoptosis. High levels of circEPSTI1 correlate with reduced survival in TNBC patients. Conclusions:The circEPSTI1-miR-4753/6809-BCL11A axis affect the proliferation and apoptosis of triple-negative breast cancer through the mechanism of competing endogenous RNAs (ceRNA). In addition, our results identify circEPSTI1 as an independent prognostic marker for survival in patients with TNBC.	30083277	2018	circEPSTI1 as a Prognostic Marker and Mediator of Triple-Negative Breast Cancer Progression.	1	0	1	20
NA	NA	NA	NA	NA	circEPSTI1	Microarray,qRT-PCR,Luciferase assay,Western blot,etc.	Down?	Results: Knockdown of circEPSTI1 inhibits TNBC cell proliferation and induces apoptosis. In vitroand in vivo experiments indicated that circEPSTI1 binds to miR-4753 and miR-6809 as a miRNA sponge to regulate BCL11A expression and affect TNBC proliferation and apoptosis. High levels of circEPSTI1 correlate with reduced survival in TNBC patients. Conclusions:The circEPSTI1-miR-4753/6809-BCL11A axis affect the proliferation and apoptosis of triple-negative breast cancer through the mechanism of competing endogenous RNAs (ceRNA). In addition, our results identify circEPSTI1 as an independent prognostic marker for survival in patients with TNBC.	30083277	2018	circEPSTI1 as a prognostic marker and mediator of triple-negative breast cancer progression.	1	0	1	21
NA	NA	NA	NA	NA	circFBXW7	qRT-PCR,Luciferase Assay,RIP,Western Blot,etc.	Down?	As shown inFigure 6A, the linearized FBXW7-185aa open readingframe (ORF) and a FLAG tag were cloned into a plasmid (FBXW7-185aa-FLAG). Overexpression of FBXW7-185aa did not affect theexpression level of the circFBXW7 transcript, as measured by qRT-PCR (Figure 6B). Subsequently, we conducted CCK-8, colony forma-tion, and transwell assays to assess the influence of FBXW7-185aa onTNBC cell growth and proliferation. FBXW7-185aa significantly in-hibited the growth, colony-forming, and migration abilities ofBT549 cells (Figures 6CC6E). Additionally, the prooncogenic effectenhanced by sh-circFBXW7 was reversed after cotransfection withmiR-197-3p inhibitors and the FBXW7-185aa protein expressionplasmid (Figures 6F and 6G). Western blot analysis revealed thatoverexpression of FBXW7-185aa increased the abundance ofFBXW7 and induced c-Myc degradation. Overexpressing USP28reduced the expression of FBXW7 and suppressed FBXW7-185aa-induced c-Myc destabilization (Figure 6H). In summary, circFBXW7sponges miR-197-3p and encodes the FBXW7-185aa protein to sup-press TNBC progression though upregulating FBXW7 expression(Figure 6I).	31536884	2019	circFBXW7 Inhibits Malignant Progression by Sponging miR-197-3p and Encoding a 185-aa Protein in Triple-Negative Breast Cancer.	0	0	1	22
NA	NA	NA	NA	NA	circFoxo3	Luciferase assay,Western blot,qRT-PCR,etc.	Down	Generation of GFP-Foxo3-Fu: this construct contained the GFP andFoxo3 fusion protein. GFP was amplified by two primers EGFP-347F andEGFP-CApaI, followed by digestion withXhoICApaI. Foxo3 was amplifiedwith two primers ciR-FoxN-ApaI and ciR-FoxC-XbaI (cut withApaICXbaI).The plasmid pEGFP-N1 was cut withXhoICXbaI, followed by insertion of theGFP and Foxo3 fragments.	26657152	2016	Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition oftumor growth and angiogenesis	1	0	1	23
NA	NA	NA	NA	NA	circGFRA1	Microarray,qRT-PCR,Luciferase assay,RIP,Western blot,etc.	Down	Results: Microarray analysis and qRT-PCR verified a circRNA termed circGFRA1 that was upregulated in TNBC. Kaplan-Meier survival analysis showed that upregulated circGFRA1 was correlated with poorer survival. Knockdown of circGFRA1 inhibited proliferation and promoted apoptosis in TNBC. Via luciferase reporter assays, circGFRA1 and GFRA1 was observed to directly bind to miR-34a. Subsequent experiments showed that circGFRA1 and GFRA1 regulated the expression of each other by sponging miR-34a.Conclusions: Taken together, we conclude that circGFRA1 may function as a competing endogenous RNA (ceRNA) to regulate GFRA1 expression through sponging miR-34a to exert regulatory functions in TNBC. circGFRA1 may be a diagnostic biomarker and potential target for TNBC therapy. 	29037220	2017	circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a. 	0	0	1	24
NA	NA	NA	NA	NA	circGFRA1	qRT-PCR,Microarray,Luciferase assay,RIP,Western blot,etc.	Down?	Results:Microarray analysis and qRT-PCR verified a circRNA termed circGFRA1 that was upregulated in TNBC. Kaplan-Meier survival analysis showed that upregulated circGFRA1 was correlated with poorer survival. Knockdown ofcircGFRA1 inhibited proliferation and promoted apoptosis in TNBC. Via luciferase reporter assays, circGFRA1 and GFRA1was observed to directly bind to miR-34a. Subsequent experiments showed that circGFRA1 and GFRA1 regulated theexpression of each other by sponging miR-34a.Conclusions:Taken together, we conclude that circGFRA1 may function as a competing endogenous RNA (ceRNA) toregulate GFRA1 expression through sponging miR-34a to exert regulatory functions in TNBC. circGFRA1 may be adiagnostic biomarker and potential target for TNBC therapy.	29037220	2017	circGFRA1 and GFRA1 act as ceRNAs in tri-ple negative breast cancer by regulating miR-34a.	0	0	1	25
NA	NA	NA	NA	NA	circGFRA1 	etc.	up	ncRNAs are dysregulated in breast cancer and miRNAs, noted for their stability, and lncRNAs arebeing investigated as biomarkers of disease pathology, prognostic indicators, and potential therapeutictargets, as well as modalities to block cancer progression and metastasis. We know much moreabout miRNAs than lncRNAs in human breast tumors. Our understanding of the networks betweenmiRNAs, lncRNAs, their interacting partners, and targets is expanding. However, individual andcombinations of miRNAs and lncRNAs have cell-specific activities that are not fully understood,nor is their interaction with the immune system, microbiome, microenvironment, hormonal milieu,or metabolome elucidated. Further investigation is needed to bring studies on miRNAs and lncRNAsinto clinical practice for diagnosis, prognosis, and therapeutics in breast cancer patients	30545127	2018	Non-Coding RNAs in Breast Cancer: Intracellular and Intercellular Communication.	0	0	0	26
NA	NA	NA	NA	NA	circHMCU	qRT-PCR,Luciferase assay,RIP,etc.	up	In summary, our study found a circRNA, circHMCU, which was upregulated in breast 365 cancer tissues and correlated with poor prognosis. Further study revealed that 366 circHMCU could significantly promote proliferation and metastasis abilities of breast 367 cancer cells both in vitro and in vivo. Mechanistically, we found that circHMCU 368 could functioned as a microRNA sponge for let-7 family, which was validated by RIP 369 and luciferase reporter assay. Let-7 family is a well-known tumor suppressor because 370 of its formidable function and is considered as a potential diagnostic and prognostic 371 marker. Our study identified circHMCU as a microRNA sponge of let-7 family which 372 have important significance in understanding the regulatory function of let-7 in breast 373 cancer.	32330870	2020	circHMCU Promotes Proliferation and Metastasis of Breast Cancer by Sponging the let-7 Family.	0	0	0	27
NA	NA	NA	NA	NA	circIRAK3	etc.	differential expression	ncRNAs are dysregulated in breast cancer and miRNAs, noted for their stability, and lncRNAs arebeing investigated as biomarkers of disease pathology, prognostic indicators, and potential therapeutictargets, as well as modalities to block cancer progression and metastasis. We know much moreabout miRNAs than lncRNAs in human breast tumors. Our understanding of the networks betweenmiRNAs, lncRNAs, their interacting partners, and targets is expanding. However, individual andcombinations of miRNAs and lncRNAs have cell-specific activities that are not fully understood,nor is their interaction with the immune system, microbiome, microenvironment, hormonal milieu,or metabolome elucidated. Further investigation is needed to bring studies on miRNAs and lncRNAsinto clinical practice for diagnosis, prognosis, and therapeutics in breast cancer patients	30545127	2018	Non-Coding RNAs in Breast Cancer: Intracellular and Intercellular Communication.	0	0	0	28
NA	NA	NA	NA	NA	circIRAK3	Microarray,qRT-PCR,FISH,RIP,Luciferase assay,Western blot,etc.	up	Taken together, ourfindings reveal an oncogenic role of circIRAK3in BC metastasis by sponging miR-3607 and regulating FOXC1 expres-sion. Moreover, circIRAK3 expression is significantly increased in me-tastatic BC cells and is correlated with a high risk of recurrence indistant organs and the poor prognosis of BC patients. Therefore,circIRAK3 might act as a potential predictor and therapeutic target formetastatic BC.	29803789	2018	CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis.	0	0	1	29
NA	NA	NA	NA	NA	circITCH	Luciferase assay,Western blot,etc.	up	To the best of our knowledge, this is the first study investigating circ-research established that circ-ITCH is a tumor suppressor and a promising prognostic biomarker for TNBC, and results also revealed that circ-ITCH inhibits TNBC progression by inactivating the Wnt/-catenin pathway throughregulation of the miR-214/ miR-17/ITCH axis. Further studies, however, are warranted to explore its role in other diseases. 	30509108	2019	Circ-ITCH regulates triple-negative breast cancer progression through the Wnt/-catenin pathway.	0	0	1	30
NA	NA	NA	NA	NA	circKDM4C	qRT-PCR,western blot,RIP,Luciferase assay,etc.	up	In summary, we demonstrated for thefirst time thatcircKDM4C was downregulated in breast cancer tissues andcell lines. Our results not only elucidate the potentialmechanism by which circRNAs regulate the progressionand chemoresistance of breast cancer, but also suggest thatthe circKDM4C/miR-548p/ PBLD axis could be a potentialtherapeutic target for breast cancer patients.	31406252	2019	circKDM4C suppresses tumor progression and attenuates doxorubicin resistance by regulating miR-548p/PBLD axis in breast cancer.	1	0	1	31
NA	NA	NA	NA	NA	circKIF4A	qRT-PCR,Luciferase Assay,RIP,Western Blot,etc.	up	Results:qRT-PCR analyses verified that circKIF4A was significantly upregulated and positively associated with poorersurvival of TNBC. The inhibition of circKIF4A suppressed cell proliferation and migration in TNBC. Luciferase reporterassay and RNA immunoprecipitation assay revealed that circKIF4A and KIF4A could bind to miR-375 and thatcircKIF4A regulated the expression of KIF4A via sponging miR-375.Conclusions:The circKIF4A-miR-375-KIF4A axis regulates TNBC progression via the competitive endogenous RNA(ceRNA) mechanism. circKIF4A may therefore serve as a prognostic biomarker and therapeutic target for TNBC.	30744636	2019	circKIF4A acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer.	0	0	1	32
NA	NA	NA	NA	NA	circKIF4A	qRT-PCR,luciferase assay,RIP,Western blot,etc.	Down?	Results:qRT-PCR analyses verified that circKIF4A was significantly upregulated and positively associated with poorersurvival of TNBC. The inhibition of circKIF4A suppressed cell proliferation and migration in TNBC. Luciferase reporterassay and RNA immunoprecipitation assay revealed that circKIF4A and KIF4A could bind to miR-375 and thatcircKIF4A regulated the expression of KIF4A via sponging miR-375.Conclusions:The circKIF4A-miR-375-KIF4A axis regulates TNBC progression via the competitive endogenous RNA(ceRNA) mechanism. circKIF4A may therefore serve as a prognostic biomarker and therapeutic target for TNBC.	30744636	2019	circKIF4A acts as a prognostic fac-tor and mediator to regulate the progression of triple-negative breast cancer. 	0	0	1	33
NA	NA	NA	NA	NA	circMYO9B	qRT-PCR,Luciferase assay,etc.	up	In conclusion, we demonstrated that circMYO9B plays an essential role in regulating BC cell proliferation, migration and invasion through sponging miR-4316 to increase FOXP4 expression for the first time. And circMYO9B might be a potential prognostic biomarker in BC.	29702064	2018	Circular RNA circMYO9B facilitates breast cancer cell proliferation and invasiveness via upregulating FOXP4 expression by sponging miR-4316.	0	0	1	34
NA	NA	NA	NA	NA	circPLK1	Microarray,Luciferase assay,RNAi,Western blot,etc.	up	This study showed that circPLK1 is significantly upregulated in TNBC and associated with worse clinical outcomes.CircPLK1 is found to regulatePLK1expression via binding to miR-296-5p as a sponge in TNBC cell proliferationand metastasis. Therefore, circPLK1 may serve as a potential biomarker for prognosis and promising target forTNBC therapy.	31337246	2019	CircPLK1 sponges miR-296-5p to facilitate triple-negative breast cancer progression.	0	0	1	35
NA	NA	NA	NA	NA	circPLK1	Microarray,qRT-PCR,Luciferase assay,RNAi,Western blot,etc.	Up	Results & conclusion:CircPLK1 was significantly upregulated in TNBC and associated with poor sur-vivals. CircPLK1 knockdown inhibited cell growth and invasionin vitroas well as tumor occurrence andmetastasisin vivo. CircPLK1-miR-296-5p-PLK1axis regulates tumor progression by ceRNA mechanism inTNBC, indicating that circPLK1 may serve as a prognostic factor and novel therapeutic target for TNBC	31337246	2019	CircPLK1 sponges miR-296-5p to facilitate triple-negative breast cancer progression. 	0	0	1	36
NA	NA	NA	NA	NA	circRAD18	qRT-PCR,luciferase assay,Western Blot,etc.	up	In summary, our study indicates circRAD18 is upregulated and correlated with more advanced stages and worse clinical outcomes in TNBC. CircRAD18 promotes cell proliferation, migration and inhibites apoptosis through sponging miR-208a/3164 to enhance IGF1 and FGF2 expression. Therefore, circRAD18 may serve as a novel prognostic biomarker and potential therapeutic target for TNBC in the future	31001629	2019	circRAD18 sponges miR-208a/3164 to promote triple-negative breast cancer progression through regulating IGF1 and FGF2 expression.	0	0	1	37
NA	NA	NA	NA	NA	circRAD18	qRT-PCR,luciferase assay,Western Blot,etc.	Up	In summary, our study indicates circRAD18 isup-regulated and correlated with more advanced stages and worseclinical outcomes in TNBC. CircRAD18 promotescell proliferation, migrationand inhibitesapoptosisthrough sponging miR-208a/3164 to enhance IGF1and FGF2expression. Therefore, circRAD18 may serve as a novel prognostic biomarker and potential therapeutic target for TNBC in the future.	31001629	2019	circRAD18 sponges miR-208a/3164 to promote triple-negative breast cancer progression through regulating IGF1 and FGF2 expression. 	0	0	1	38
NA	NA	NA	NA	NA	has_circ_0025202	qRT-PCR,Luciferase Assay,RIP,Western Blot,etc.	down	In this study, wefirst analyzed the expression profile ofcircRNAs from TAM-resistant MCF-7 (MCF7/TR) and parentalMCF-7 (MCF7/P) cells, and we characterized a novel circRNA,hsa_circ_0025202, which was significantly downregulated inMCF7/TR cells. Furthermore, the roles of hsa_circ_0025202 inTAM resistance and BC progression were studied	31153828	2019	circRNA_0025202 Regulates Tamoxifen Sensitivity and Tumor Progression via Regulating the miR-182-5p/FOXO3a Axis in Breast Cancer.	1	0	0	39
NA	NA	NA	NA	NA	has_circ_069718	qRT-PCR,Western Blot,etc.	up	We showed that circRNA_069718 could act as a tumor oncogenic circRNA in TNBC progres-sion. The knockdown of circRNA_069718 could reduce cell proliferation and invasion in TNBC by inactivating the Wnt/-catenin pathway. Thus, our study suggested that circRNA_069718 could function as a potential therapeutic target for BC treatment.	31298383	2019	CircRNA_069718 promotes cell proliferation and invasion in triple-negative breast cancer by activating Wnt/-catenin pathway.	0	0	1	40
NA	NA	NA	NA	NA	has_circ_069718	qRT-PCR,Western Blot,etc.	Down?	Results: We found that circRNA_069718 expression was significantly increased in TNBC tissues and cell lines. High circRNA_069718 expression was significantly correlated with advanced TNM stage, lymph node metastasis, and poor overall survival of TNBC patients. Functionally, we showed that circRNA_069718 inhibition significantly reduced TNBC cells proliferation and invasion ability in vitro. Mechanically, we found that circRNA_069718 inhibition reduced the expression levels of Wnt/-catenin pathway-related genes (-catenin, c-myc, and cyclin D1).Conclusions: Our findings suggested that circRNA_069718 promoted TNBC progression via Wnt/-catenin pathway and could serve as a novel therapeutic target for TNBC treatment. 	31298383	2019	CircRNA_069718 promotes cell proliferation and invasion in triple-negative breast cancer by activating Wnt/beta-catenin pathway	0	0	1	41
NA	NA	NA	NA	NA	has_circ_100876	qRT-PCR,Luciferase Assay,etc.	up	RESULTS : QRT-PCR results showed that cir-cRNA_100876 level in BC tissues was conspic-uously higher than that in the adjacent tis-sues, and the patients with distant metasta-sis had higher expression than those without. Moreover, patients with a high expression of circRNA_100876 had a relatively lower over-all survival rate. Compared with the NC group, the cell proliferation and invasion ability of cir-cRNA_100876 knockdown group was conspic-uously decreased. QRT-PCR revealed that mi-croRNA-361-3p and circRNA_100876 showed a negative correlation in the expression level of genes in BC tissues. In addition, the results of the Luciferase reporter gene assay confirmed that circRNA_100876 can be targeted by microR-NA-361-3p through their binding site.CONCLUSIONS: High expression of cir-cRNA_100876 is conspicuously positively rele-vant to poor prognosis of BC patients. Addition-ally, circRNA_100876 is able to promote BC me-tastasis as well as proliferative capacity by mod-ulating microRNA-361-3p expression	31486496	2019	CircRNA_100876 promote proliferation and metastasis of breast cancer cells through adsorbing microRNA-361-3p in a sponge form.	0	0	1	42
NA	NA	NA	NA	NA	has_circ_103809	qRT-PCR,luciferase assay,Western Blot,etc.	Down?	To sum up, this study showed that the overexpression of circRNA_103809 could directly regulated the function of miR-532-3p, followed by arrest at G2/M phase and suppression of cell proliferation and metastasis via interfering EMT signaling pathway in breast cancer. However, there are some limitations in this study. That is, the molecules downstream of the circRNA_103809/miR-532-3p axis are unknown, and in vivo anti-tumor effect induced by circRNA_103809 overexpression are unclear. Overall, our findings indicate that circRNA_103809 might be a promising target for breast cancer therapy.	32499818	2020	CircRNA_103809 Suppresses the Proliferation and Metastasis of Breast Cancer Cells by Sponging MicroRNA-532-3p (miR-532-3p).	0	0	1	43
NA	NA	NA	NA	NA	has_circ_1093	qRT-PCR,etc.	up	Results: A total of 6,824 and 4,523 circRNAs were identified from rat mammary glands at two different lactation stages. Numerous circRNAs were specifically expressed at different lactation stages, and only 1,314 circRNAs were detected at both lactation stages. The majority of the candidate circRNAs map to noncoding intronic and intergenic regions. The results demonstrate a circular preference or specificity of some genes. DAVID analysis revealed an enrichment of protein kinases and related proteins among the set of genes encoding circRNAs. Interestingly, four protein-coding genes (Rev3l, IGSF11, MAML2, and LPP) that also transcribe high levels of circRNAs have been reported to be involved in cancer.Conclusion: Our findings provide the basis for comparison between breast cancer profiles and for selecting representative circRNA candidates for future functional characterization in breast development and breast cancer. 	26472973	2015	Expression patternsof circular RNAs from primary kinase transcripts in the mammary glands oflactating rats	0	0	0	44
NA	NA	NA	NA	NA	has_circ_000911	luciferase assay,qRT-PCR,etc.	up	In conclusion, in this study, and to the best of our knowledge, we report for the first time that circRNA?000911 plays an anti?oncogenic role in breast cancer. Moreover, circRNA-000911 exerts its function by serving as a miRNA sponge for miR-449a and thereby promoting the function of Notch1 and the NF-B signaling pathway. Therefore, circRNA-000911 may serve as a promising predictive biomarker and therapeutic target for patients with breast cancer	29431182	2018	Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis.	0	0	1	45
NA	NA	NA	NA	NA	circCER	Western blot,etc	down	The present study aimed to evaluate the expression profiles of circRNA-CER in breast cancer and investigate their potential role in the disease. The data demonstrated that the expression levels of circRNA-CER in breast cancer tissue were significantly higher compared with in adjacent non-tumor tissue, and that circRNA-CER may function as a competing endogenous RNA to regulate the expression of MMP13 by competing with miR-136 in breast cancer cells. To the best of our knowledge the present study demonstrated for the first time a positive circRNA?CER/MMP13 association, and crosstalk among miR-136, circRNA-CER and MMP13, which provides novel insight into the treatment of breast cancer.	30816475	2019	circRNA?CER mediates malignant progression of breast cancer through targeting the miR?136/MMP13 axis.	0	0	1	46
NA	NA	NA	NA	NA	circSEPT9	RNA-seq,FISH,qRT-PCR,Luciferase assay,RIP,Western blot,etc.	up	Results: Increased expression of circSEPT9 was found in TNBC tissues, which was positively correlated with advanced clinical stage and poor prognosis. Knockdown of circSEPT9 significantly suppressed the proliferation, migration and invasion of TNBC cells, induced apoptosis and autophagy in TNBC cells as well as inhibited tumor growth and metastasis in vivo. Whereas up-regulation of circSEPT9 exerted opposite effects. Further mechanism research demonstrated that circSEPT9 could regulate the expression of Leukemia Inhibitory Factor (LIF) via sponging miR-637 and activate LIF/Stat3 signaling pathway involved in progression of TNBC. More importantly, we discovered that E2F1 and EIF4A3 might promote the biogenesis of circSEPT9.Conclusions: Our data reveal that the circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer through circSEPT9/miR-637/LIF axis. Therefore, circSEPT9 could be used as a potential prognostic marker and therapeutical target for TNBC. 	32264877	2020	The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer.	0	0	1	47
NA	NA	NA	NA	NA	circTADA2As	microarray,etc.	down	They were consistently and significantlydecreased in a large cohort of breast cancer patients, and their downregulation was associated with poor patientsurvival for TNBC. Especially, circTADA2A-E6 suppressed in vitro cell proliferation, migration, invasion, andclonogenicity and possessed tumor-suppressor capability. circTADA2A-E6 preferentially acted as a miR-203a-3psponge to restore the expression of miRNA target geneSOCS3, resulting in a less aggressive oncogenic phenotype.circTADA2As as promising prognostic biomarkers in TNBC patients, and therapeutic targeting of circTADA2As/miRNA/mRNA network may be a potential strategy for the treatment of breast cancer.	30787278	2019	circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis.	1	0	1	48
NA	NA	NA	NA	NA	circUBAP2	qRT-PCR,FISH,RIP,Luciferase assay,Western blot,	Down?	Collectively, in this study, we identified circ-UBAP2 as a noveloncogenic circRNA that regulates the miR-661/MTA1 pathway, aswell as a potential prognostic biomarker in TNBC. Targeted therapyof circ-UBAP2 may be a new therapeutic strategy for patients withTNBC.	30314706	2018	Upregulation of circ-UBAP2 predicts poor prognosis and promotes triple-negative breast cancer pro-gression through the miR-661/MTA1 pathway	0	0	1	49
NA	NA	NA	NA	NA	circUBAP2	Luciferase assay,RIP,FISH,qRT-PCR,Western blot,etc.	up	Collectively, in this study, we identified circ-UBAP2 as a noveloncogenic circRNA that regulates the miR-661/MTA1 pathway, aswell as a potential prognostic biomarker in TNBC. Targeted therapyof circ-UBAP2 may be a new therapeutic strategy for patients withTNBC.	30314706	2018	Upregulation of circ-UBAP2 predicts poor prognosis and promotes triple-negative breast cancer progression through the miR-661/MTA1 pathway.	0	0	1	50
NA	NA	NA	NA	NA	has_circ_100219	luciferase assay,Western blot,qRT-PCR,etc.	up	Conclusions: Overexpression of circ-10021 promotes the proliferative and migratory capacities of breast cancer cells by sponging microRNA-485-3p to upregulate the NTRK3 expression.	31127997	2019	Circular RNA-100219 promotes breast cancer progression by binding to microRNA-485-3p.	0	0	0	51
NA	NA	NA	NA	NA	circMTO1	Western blot,etc.	down	In conclusion, the results of the present study indicated a circRNA-involved regulatory pattern to mediate Eg5 protein expression during monastrol resistance. First, monastrol resis-tance induced downregulated circRNA-MTO1 expression in breast cancer cells. Second, overexpression of MTO1 repressed viability and reversed monastrol resistance through inhibiting Eg5 protein level and associating with TRAF4. Therefore, circRNA-MTO1 may be a functional regulatory factor of breast cancer, and restoration of MTO1 levels could be a future direction to overcome breast cancer chemoresistance.	30015883	2018	Circular RNA?MTO1 suppresses breast cancer cell viability and reverses monastrol resistance through regulating the TRAF4/Eg5 axis.	1	0	1	52
NA	NA	NA	NA	NA	circVRK1	Western blot,qRT-PCR,etc.	Down	In conclusion, the current work was the first to indicate the circRNA signature of BCSCs. We determined the circRNA/miRNA network and analysed the potential functional roles of dysregulated circRNAs. Furthermore, we revealed that circVRK1 was capable to negatively regulate the stemness of BCSCs. Our findings strengthen the possibility that circVRK1 is able to serve as a potential target for BCSCs. Additionally, the current data also provide supports for further study on circRNAs in stemness maintenance of BCSCs.	29221160	2017	Circular RNA profileindicates circular RNA VRK1 is negatively related with breast cancer stemcells	0	0	0	53
NA	NA	NA	NA	NA	circZNF609	qRT-PCR,luciferase assay,Western Blot,etc.	up	These data suggest that circZNF609 contributes to breast cancer progression, at least partly, by modulating the miR-145-5p/p70S6K1 axis, and it may be a potential therapeutic target for breast cancer.	30288120	2018	CircZNF609 promotes breast cancer cell growth, migration, and invasion by elevating p70S6K1 via sponging miR-145-5p.	1	0	1	54
chr1	1158623	1159348	-	SDF4	hsa_circ_0000002	qRT-PCR,etc.	down	Results: A total of 215 upregulated and 191 downregulated circRNAs were identified. The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002. CircRNA/miRNA analysis revealed that hsa_circ_0001944 may be involved in BCBM through sponging up miR-509 and interfering with its binding to the downstream targets.Conclusion: This study provides a leading and fundamental circRNA profile of BCBM. 	30810051	2018	Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.	0	0	0	55
chr15	83819966	83832827	-	HDGFRP3	hsa_circ_0000646	qRT-PCR,etc.	up	Results: A total of 215 upregulated and 191 downregulated circRNAs were identified. The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002. CircRNA/miRNA analysis revealed that hsa_circ_0001944 may be involved in BCBM through sponging up miR-509 and interfering with its binding to the downstream targets.Conclusion: This study provides a leading and fundamental circRNA profile of BCBM. 	30810051	2018	Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.	0	0	0	56
chr17	1540002	1540356	-	SCARF1	hsa_circ_0000732	qRT-PCR,etc.	up	Results: A total of 215 upregulated and 191 downregulated circRNAs were identified. The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002. CircRNA/miRNA analysis revealed that hsa_circ_0001944 may be involved in BCBM through sponging up miR-509 and interfering with its binding to the downstream targets.Conclusion: This study provides a leading and fundamental circRNA profile of BCBM. 	30810051	2018	Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.	0	0	0	57
chr2	55209650	55214834	-	RTN4	hsa_circ_0001006	qRT-PCR,etc.	up	Results: A total of 215 upregulated and 191 downregulated circRNAs were identified. The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002. CircRNA/miRNA analysis revealed that hsa_circ_0001944 may be involved in BCBM through sponging up miR-509 and interfering with its binding to the downstream targets.Conclusion: This study provides a leading and fundamental circRNA profile of BCBM. 	30810051	2018	Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.	0	0	0	58
chr5	49694940	49707217	-	EMB	hsa_circ_0001481	qRT-PCR,etc.	up	Results: A total of 215 upregulated and 191 downregulated circRNAs were identified. The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002. CircRNA/miRNA analysis revealed that hsa_circ_0001944 may be involved in BCBM through sponging up miR-509 and interfering with its binding to the downstream targets.Conclusion: This study provides a leading and fundamental circRNA profile of BCBM. 	30810051	2018	Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.	0	0	0	59
chr5	49694940	49707217	-	EMB	hsa_circ_0001481	qRT-PCR,etc.	up	Results: A total of 215 upregulated and 191 downregulated circRNAs were identified. The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002. CircRNA/miRNA analysis revealed that hsa_circ_0001944 may be involved in BCBM through sponging up miR-509 and interfering with its binding to the downstream targets.Conclusion: This study provides a leading and fundamental circRNA profile of BCBM. 	30810051	2018	Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.	0	0	0	60
chrX	10031484	10066619	+	WWC3	hsa_circ_0001910	qRT-PCR,etc.	down	Results: A total of 215 upregulated and 191 downregulated circRNAs were identified. The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002. CircRNA/miRNA analysis revealed that hsa_circ_0001944 may be involved in BCBM through sponging up miR-509 and interfering with its binding to the downstream targets.Conclusion: This study provides a leading and fundamental circRNA profile of BCBM. 	30810051	2018	Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.	0	0	0	61
chr6	4891946	4892613	+	CDYL	hsa_circ_0008285	qRT-PCR,etc.	down	Results: A total of 215 upregulated and 191 downregulated circRNAs were identified. The expression levels of ten randomly selected majorly altered circRNAs were re-examined by real-time quantitative PCR and agarose gel electrophoresis, and the following alterations were verified: upregulation of hsa_circ_0001944, hsa_circ_0001481, hsa_circ_0000646, hsa_circ_0001006 and hsa_circ_0000732, and downregulation of hsa_circ_0001910, hsa_circ_0008285 and hsa_circ_0000002. CircRNA/miRNA analysis revealed that hsa_circ_0001944 may be involved in BCBM through sponging up miR-509 and interfering with its binding to the downstream targets.Conclusion: This study provides a leading and fundamental circRNA profile of BCBM. 	30810051	2018	Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.	0	0	0	62
chr1	58992932	59002413	-	OMA1	hsa_circ_0000073	Microarray,qRT-PCR,luciferase assay,etc.	Up	In summary, our study verifies the circRNA expressionprofiles using microarray analysis and uncovers hsa_circhsa_circ_0001982 to explore its physiological function, providinga novel perspective on the biogenesis, biological function,oncogenesis, progression, and possible therapies for breastcancer involving circRNAs.	28933584	2017	Circular RNA hsa_circ_0001982 Promotes Breast CancerCell Carcinogenesis Through Decreasing miR-143	0	0	0	63
chr12	6657590	6657991	-	IFFO1	hsa_circ_0000375	etc.	Down	We successfully established a ceRNA network to describe thepossible mechanisms of breast cancer, which can shed light on thecircRNA-related ceRNA network in breast cancer. The currentstudy shows that hsa_circ_0000519 may play important roles inbreast cancer. Thesefindings may provide potential biomarkersor therapeutic targets for breast cancer patien	31725681	2019	Identification of breast cancer-related circRNAs by analysis of microarray and RNA-sequencing data: An observational study.	0	1	1	64
chr12	11199618	11248400	-	PRH1-PRR4	hsa_circ_0000376	etc.	Down	We successfully established a ceRNA network to describe thepossible mechanisms of breast cancer, which can shed light on thecircRNA-related ceRNA network in breast cancer. The currentstudy shows that hsa_circ_0000519 may play important roles inbreast cancer. Thesefindings may provide potential biomarkersor therapeutic targets for breast cancer patien	31725681	2019	Identification of breast cancer-related circRNAs by analysis of microarray and RNA-sequencing data: An observational study.	0	1	1	65
chr13	43528083	43544806	-	EPSTI1	hsa_circ_0000479	Microarray,qRT-PCR,Luciferase assay,Western blot,etc.	up	In summary, we have proposed a comprehensivemethod to systematically screen breast cancer specificcircular RNAs through integrating an in silico pipelinewith in vitro and ex vivo techniques. We highlighted thathsa_circ_001783 as a novel prognostic marker for breastcancer and uncovered its new mechanism in regulat-ing cancer proliferation and metastasis via sponging miR-200c-3p. Thus, this circular RNA might be a potentialtherapeutic target for breast cancer treatment.	30083277	2019	circEPSTI1 as a prognostic marker and mediator of triple-negative breast cancer progression.	0	1	1	66
NA	NA	NA	NA	NA	hsa_circ_0000479?	Microarray,qRT-PCR,Luciferase assay,Western blot,etc.	up	Results: Knockdown of circEPSTI1 inhibits TNBC cell proliferation and induces apoptosis. In vitroand in vivo experiments indicated that circEPSTI1 binds to miR-4753 and miR-6809 as a miRNA sponge to regulate BCL11A expression and affect TNBC proliferation and apoptosis. High levels of circEPSTI1 correlate with reduced survival in TNBC patients. Conclusions:The circEPSTI1-miR-4753/6809-BCL11A axis affect the proliferation and apoptosis of triple-negative breast cancer through the mechanism of competing endogenous RNAs (ceRNA). In addition, our results identify circEPSTI1 as an independent prognostic marker for survival in patients with TNBC	30083277	2018	circEPSTI1 as a prognostic marker and mediator of triple-negative breast cancer progression	1	0	1	67
chr14	20811398	20811483	+	RPPH1	hsa_circ_0000516	etc.	Up	We successfully established a ceRNA network to describe thepossible mechanisms of breast cancer, which can shed light on thecircRNA-related ceRNA network in breast cancer. The currentstudy shows that hsa_circ_0000519 may play important roles inbreast cancer. Thesefindings may provide potential biomarkersor therapeutic targets for breast cancer patien	31725681	2019	Identification of breast cancer-related circRNAs by analysis of microarray and RNA-sequencing data: An observational study.	0	1	1	68
chr14	20811404	20811492	-	RPPH1	hsa_circ_0000517	etc.	Up	We successfully established a ceRNA network to describe thepossible mechanisms of breast cancer, which can shed light on thecircRNA-related ceRNA network in breast cancer. The currentstudy shows that hsa_circ_0000519 may play important roles inbreast cancer. Thesefindings may provide potential biomarkersor therapeutic targets for breast cancer patien	31725681	2019	Identification of breast cancer-related circRNAs by analysis of microarray and RNA-sequencing data: An observational study.	0	1	1	69
chr14	20811436	20811534	-	RPPH1	hsa_circ_0000519	etc.	Up	We successfully established a ceRNA network to describe thepossible mechanisms of breast cancer, which can shed light on thecircRNA-related ceRNA network in breast cancer. The currentstudy shows that hsa_circ_0000519 may play important roles inbreast cancer. Thesefindings may provide potential biomarkersor therapeutic targets for breast cancer patien	31725681	2019	Identification of breast cancer-related circRNAs by analysis of microarray and RNA-sequencing data: An observational study.	0	1	1	70
chr19	17448965	17449496	-	GTPBP3	hsa_circ_0000911	qRT-PCR,luciferase assay,RIP,Western blot,etc.	Down?	In conclusion, in this study, and to the best of our knowledge, we report for the first time that circRNA-000911 plays an anti-oncogenic role in breast cancer. Moreover, circRNA-000911 exerts its function by serving as a miRNA sponge for miR-449a and thereby promoting the function of Notch1 and the NF-B signaling pathway. Therefore, circRNA-000911 may serve as a promising predictive biomarker and therapeutic target for patients with breast cancer.	29431182	2018	Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis	0	1	1	71
NA	NA	NA	NA	NA	hsa_circ_0001098	qRT-PCR,western blot,luciferase assay,etc.	down	This study demonstrated the function of TCDD/cricRNA_BARD1/miR-3942-3p/BARD1 axis in breast cancer development for the first time. However, the internal mechanisms that TCDD up-regulated circRNA_BARD1 remain to be studied. Furthermore, the downstream signaling of BARD1 could be further explored. In conclusion, circRNA-BARD1 was remarkably up-regulated in breast cancer with TCDD treatment and inhibited carcinogenesis via regulating miR-3942-3p and BARD1. TCDD/cricRNA_BARD1/miR-3942-3p/BARD1 axis could be a novel regulator in the therapy of breast cancer. 	30521417	2018	Circlular RNA BARD1 (Hsa_circ_0001098) overexpression in breast cancer cells with TCDD treatment could promote cell apoptosis via miR-3942/BARD1 axis.	0	0	0	72
chr20	30345209	30370193	+	TPX2	hsa_circ_0001135	Microarray,qRT-PCR,luciferase assay,etc.	Down	ncRNAs are dysregulated in breast cancer and miRNAs, noted for their stability, and lncRNAs arebeing investigated as biomarkers of disease pathology, prognostic indicators, and potential therapeutictargets, as well as modalities to block cancer progression and metastasis. We know much moreabout miRNAs than lncRNAs in human breast tumors. Our understanding of the networks betweenmiRNAs, lncRNAs, their interacting partners, and targets is expanding. However, individual andcombinations of miRNAs and lncRNAs have cell-specific activities that are not fully understood,nor is their interaction with the immune system, microbiome, microenvironment, hormonal milieu,or metabolome elucidated. Further investigation is needed to bring studies on miRNAs and lncRNAsinto clinical practice for diagnosis, prognosis, and therapeutics in breast cancer patients	30545127	2018	Circular RNA hsa_circ_0001982 promotes breast cancer cell carcinogenesis through decreasing miR-143	0	0	1	73
chr22	51024958	51033691	+	TCONS_00029632	hsa_circ_0001259	Microarray,qRT-PCR,luciferase assay,etc.	Down	ncRNAs are dysregulated in breast cancer and miRNAs, noted for their stability, and lncRNAs arebeing investigated as biomarkers of disease pathology, prognostic indicators, and potential therapeutictargets, as well as modalities to block cancer progression and metastasis. We know much moreabout miRNAs than lncRNAs in human breast tumors. Our understanding of the networks betweenmiRNAs, lncRNAs, their interacting partners, and targets is expanding. However, individual andcombinations of miRNAs and lncRNAs have cell-specific activities that are not fully understood,nor is their interaction with the immune system, microbiome, microenvironment, hormonal milieu,or metabolome elucidated. Further investigation is needed to bring studies on miRNAs and lncRNAsinto clinical practice for diagnosis, prognosis, and therapeutics in breast cancer patients	30545127	2018	Circular RNA hsa_circ_0001982 promotes breast cancer cell carcinogenesis through decreasing miR-143	0	0	1	74
chr6	35286005	35286122	-	DEF6	hsa_circ_0001598	Microarray,qRT-PCR,luciferase assay,etc.	Up	In summary, our study verifies the circRNA expressionprofiles using microarray analysis and uncovers hsa_circhsa_circ_0001982 to explore its physiological function, providinga novel perspective on the biogenesis, biological function,oncogenesis, progression, and possible therapies for breastcancer involving circRNAs.	28933584	2017	Circular RNA hsa_circ_0001982 Promotes Breast CancerCell Carcinogenesis Through Decreasing miR-143	0	0	0	75
chr6	35286005	35286122	-	DEF6	hsa_circ_0001598	Microarray,qRT-PCR,luciferase assay,etc.	Up	ncRNAs are dysregulated in breast cancer and miRNAs, noted for their stability, and lncRNAs arebeing investigated as biomarkers of disease pathology, prognostic indicators, and potential therapeutictargets, as well as modalities to block cancer progression and metastasis. We know much moreabout miRNAs than lncRNAs in human breast tumors. Our understanding of the networks betweenmiRNAs, lncRNAs, their interacting partners, and targets is expanding. However, individual andcombinations of miRNAs and lncRNAs have cell-specific activities that are not fully understood,nor is their interaction with the immune system, microbiome, microenvironment, hormonal milieu,or metabolome elucidated. Further investigation is needed to bring studies on miRNAs and lncRNAsinto clinical practice for diagnosis, prognosis, and therapeutics in breast cancer patients	30545127	2018	Circular RNA hsa_circ_0001982 promotes breast cancer cell carcinogenesis through decreasing miR-143	0	0	1	76
chr8	24158722	24158893	-	ADAM28	hsa_circ_0001783	FISH,RIP,Luciferase assay,etc.	down	Importantly, hsa_circ_001783 promoted progression of breast cancer cells via sponging miR-200c-3p. Taken together, hsa_circ_001783 may serve as a novel prognostic and therapeutic target for breast cancer. 	30670688	2019	Circular RNA hsa_circ_001783 Regulates Breast Cancer Progression via Sponging miR-200c-3p	0	1	1	77
chr8	28013458	28019595	+	ELP3	hsa_circ_0001785	qRT-PCR,microarray,etc.	up	In conclusion, our study reveals that multiple circRNAs are closely correlatedwith breast cancer tumorigenesis, and thoroughlyinvestigates the diagnostic valueof hsa_circ_0001785, suggesting the promisingbiomarker for breast cancerdetection.	29045858	2018	Circulating circularRNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancerdetection	0	1	1	78
chr8	28013458	28019595	+	ELP3	hsa_circ_0001785	microarray,qRT-PCR,etc.	differential expression	In conclusion, our study reveals that multiple circRNAs are closely correlatedwith breast cancer tumorigenesis, and thoroughlyinvestigates the diagnostic valueof hsa_circ_0001785, suggesting the promisingbiomarker for breast cancerdetection.	29045858	2018	Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection.	0	1	1	79
chr8	28013458	28019595	+	ELP3	hsa_circ_0001785	microarray,qRT-PCR,etc.	up	In conclusion, our study reveals that multiple circRNAs are closely correlatedwith breast cancer tumorigenesis, and thoroughlyinvestigates the diagnostic valueof hsa_circ_0001785, suggesting the promisingbiomarker for breast cancerdetection.	29045858	2018	Circulating circular RNA hsa_circ_0001785 acts as a diagnosticbiomarker for breast cancer detection.	0	1	1	80
chr8	38879161	38880844	+	ADAM9	hsa_circ_0001791	Microarray,qRT-PCR,luciferase assay,etc.	Up	In summary, our study verifies the circRNA expressionprofiles using microarray analysis and uncovers hsa_circhsa_circ_0001982 to explore its physiological function, providinga novel perspective on the biogenesis, biological function,oncogenesis, progression, and possible therapies for breastcancer involving circRNAs.	28933584	2017	Circular RNA hsa_circ_0001982 Promotes Breast CancerCell Carcinogenesis Through Decreasing miR-143	0	0	0	81
chr8	38879161	38880844	+	ADAM9	hsa_circ_0001791	Microarray,qRT-PCR,luciferase assay,etc.	Up	ncRNAs are dysregulated in breast cancer and miRNAs, noted for their stability, and lncRNAs arebeing investigated as biomarkers of disease pathology, prognostic indicators, and potential therapeutictargets, as well as modalities to block cancer progression and metastasis. We know much moreabout miRNAs than lncRNAs in human breast tumors. Our understanding of the networks betweenmiRNAs, lncRNAs, their interacting partners, and targets is expanding. However, individual andcombinations of miRNAs and lncRNAs have cell-specific activities that are not fully understood,nor is their interaction with the immune system, microbiome, microenvironment, hormonal milieu,or metabolome elucidated. Further investigation is needed to bring studies on miRNAs and lncRNAsinto clinical practice for diagnosis, prognosis, and therapeutics in breast cancer patients	30545127	2018	Circular RNA hsa_circ_0001982 promotes breast cancer cell carcinogenesis through decreasing miR-143	0	0	1	82
chr9	33944362	33956144	-	UBAP2	hsa_circ_0001846	FISH,RIP,qRT-PCR,Luciferase assay,Western blot,etc.	up	Collectively, in this study, we identified circ-UBAP2 as a noveloncogenic circRNA that regulates the miR-661/MTA1 pathway, aswell as a potential prognostic biomarker in TNBC. Targeted therapyof circ-UBAP2 may be a new therapeutic strategy for patients withTNBC.	30314706	2018	Upregulation of circ-UBAP2 predicts poor prognosis and pro-motes triple-negative breast cancer progres-sion through the miR-661/MTA1 pathway. 	0	0	1	83
chr15	59323002	59323901	+	RNF111	hsa_circ_0001982	Microarray,qRT-PCR,luciferase assay,etc.	up	ncRNAs are dysregulated in breast cancer and miRNAs, noted for their stability, and lncRNAs arebeing investigated as biomarkers of disease pathology, prognostic indicators, and potential therapeutictargets, as well as modalities to block cancer progression and metastasis. We know much moreabout miRNAs than lncRNAs in human breast tumors. Our understanding of the networks betweenmiRNAs, lncRNAs, their interacting partners, and targets is expanding. However, individual andcombinations of miRNAs and lncRNAs have cell-specific activities that are not fully understood,nor is their interaction with the immune system, microbiome, microenvironment, hormonal milieu,or metabolome elucidated. Further investigation is needed to bring studies on miRNAs and lncRNAsinto clinical practice for diagnosis, prognosis, and therapeutics in breast cancer patients	30545127	2018	Circular RNA hsa_circ_0001982 promotes breast cancer cell carcinogenesis through decreasing miR-143	0	0	1	84
chr15	59323002	59323901	+	RNF111	hsa_circ_0001982	Microarray,qRT-PCR,luciferase assay,etc.	Down	In summary, our study verifies the circRNA expressionprofiles using microarray analysis and uncovers hsa_circhsa_circ_0001982 to explore its physiological function, providinga novel perspective on the biogenesis, biological function,oncogenesis, progression, and possible therapies for breastcancer involving circRNAs.	28933584	2017	Circular RNA hsa_circ_0001982 Promotes Breast CancerCell Carcinogenesis Through Decreasing miR-143	0	0	0	85
chr15	59323002	59323901	+	RNF111	hsa_circ_0001982	Microarray,luciferase assay,etc.	up	In summary, our study verifies the circRNA expressionprofiles using microarray analysis and uncovers hsa_circhsa_circ_0001982 to explore its physiological function, providinga novel perspective on the biogenesis, biological function,oncogenesis, progression, and possible therapies for breastcancer involving circRNAs.	28933584	2017	Circular RNA hsa_circ_0001982 Promotes Breast Cancer Cell Carcinogenesis Through Decreasing miR-143.	0	0	1	86
chr15	59323002	59323901	+	RNF111	hsa_circ_0001982	Microarray,luciferase assay,etc.	up	In summary, our study verifies the circRNA expressionprofiles using microarray analysis and uncovers hsa_circhsa_circ_0001982 to explore its physiological function, providinga novel perspective on the biogenesis, biological function,oncogenesis, progression, and possible therapies for breastcancer involving circRNAs	28933584	2017	Circular RNA hsa_circ_0001982 promotes breast cancer cell carcinogenesis through decreasing miR-143	0	0	1	87
chr17	45753774	45754493	+	KPNB1	hsa_circ_0002007	Microarray,qRT-PCR,luciferase assay,etc.	Down	ncRNAs are dysregulated in breast cancer and miRNAs, noted for their stability, and lncRNAs arebeing investigated as biomarkers of disease pathology, prognostic indicators, and potential therapeutictargets, as well as modalities to block cancer progression and metastasis. We know much moreabout miRNAs than lncRNAs in human breast tumors. Our understanding of the networks betweenmiRNAs, lncRNAs, their interacting partners, and targets is expanding. However, individual andcombinations of miRNAs and lncRNAs have cell-specific activities that are not fully understood,nor is their interaction with the immune system, microbiome, microenvironment, hormonal milieu,or metabolome elucidated. Further investigation is needed to bring studies on miRNAs and lncRNAsinto clinical practice for diagnosis, prognosis, and therapeutics in breast cancer patients	30545127	2018	Circular RNA hsa_circ_0001982 promotes breast cancer cell carcinogenesis through decreasing miR-143	0	0	1	88
chr12	121220457	121248689	-	SPPL3	hsa_circ_0002179	Microarray,qRT-PCR,luciferase assay,etc.	Down	ncRNAs are dysregulated in breast cancer and miRNAs, noted for their stability, and lncRNAs arebeing investigated as biomarkers of disease pathology, prognostic indicators, and potential therapeutictargets, as well as modalities to block cancer progression and metastasis. We know much moreabout miRNAs than lncRNAs in human breast tumors. Our understanding of the networks betweenmiRNAs, lncRNAs, their interacting partners, and targets is expanding. However, individual andcombinations of miRNAs and lncRNAs have cell-specific activities that are not fully understood,nor is their interaction with the immune system, microbiome, microenvironment, hormonal milieu,or metabolome elucidated. Further investigation is needed to bring studies on miRNAs and lncRNAsinto clinical practice for diagnosis, prognosis, and therapeutics in breast cancer patients	30545127	2018	Circular RNA hsa_circ_0001982 promotes breast cancer cell carcinogenesis through decreasing miR-143	0	0	1	89
chr16	19656207	19663412	+	C16orf62	hsa_circ_0003645	etc.	Up	We successfully established a ceRNA network to describe thepossible mechanisms of breast cancer, which can shed light on thecircRNA-related ceRNA network in breast cancer. The currentstudy shows that hsa_circ_0000519 may play important roles inbreast cancer. Thesefindings may provide potential biomarkersor therapeutic targets for breast cancer patien	31725681	2019	Identification of breast cancer-related circRNAs by analysis of microarray and RNA-sequencing data: An observational study.	0	1	1	90
chr1	32628835	32632897	+	KPNA6	hsa_circ_0003880	Microarray,qRT-PCR,luciferase assay,etc.	Up	In summary, our study verifies the circRNA expressionprofiles using microarray analysis and uncovers hsa_circhsa_circ_0001982 to explore its physiological function, providinga novel perspective on the biogenesis, biological function,oncogenesis, progression, and possible therapies for breastcancer involving circRNAs.	28933584	2017	Circular RNA hsa_circ_0001982 Promotes Breast CancerCell Carcinogenesis Through Decreasing miR-143	0	0	0	91
chr21	16386664	16415895	-	NRIP1	hsa_circ_0004771	Luciferase assay,RT-qPCR,Western blot,etc	up	In conclusion, our findings suggested that miR-653 was able to target both hsa_circ_0004771 and ZEB2, reflecting that hsa_circ_0004771 might serve as miR-653 sponge to modulate ZEB2 expression through the ceRNA mechanism. Bioinformatics prediction and luciferase reporter assays verified these conclusions. We also found that hsa_circ_0004771 performed a parallel effect to ZEB2 and an opposite effect to miR-653 in breast cancer cell proliferation and apoptosis. More importantly, hsa_circ_0004771/miR-653/ZEB2 aixs contributed to the development of the new therapeutic targets for the treatment of breast cancer.	30979827	2019	Silencing of hsa_circ_0004771 inhibits proliferation and induces apoptosis in breast cancer through activation of miR-653 by targeting ZEB2 signaling pathway.	0	0	1	92
chr3	5212187	5216099	+	ARL8B	hsa_circ_0005046	Microarray,qRT-PCR,luciferase assay,etc.	Up	In summary, our study verifies the circRNA expressionprofiles using microarray analysis and uncovers hsa_circhsa_circ_0001982 to explore its physiological function, providinga novel perspective on the biogenesis, biological function,oncogenesis, progression, and possible therapies for breastcancer involving circRNAs.	28933584	2017	Circular RNA hsa_circ_0001982 Promotes Breast CancerCell Carcinogenesis Through Decreasing miR-143	0	0	0	93
chr3	5212187	5216099	+	ARL8B	hsa_circ_0005046	Microarray,qRT-PCR,luciferase assay,etc.	Up	ncRNAs are dysregulated in breast cancer and miRNAs, noted for their stability, and lncRNAs arebeing investigated as biomarkers of disease pathology, prognostic indicators, and potential therapeutictargets, as well as modalities to block cancer progression and metastasis. We know much moreabout miRNAs than lncRNAs in human breast tumors. Our understanding of the networks betweenmiRNAs, lncRNAs, their interacting partners, and targets is expanding. However, individual andcombinations of miRNAs and lncRNAs have cell-specific activities that are not fully understood,nor is their interaction with the immune system, microbiome, microenvironment, hormonal milieu,or metabolome elucidated. Further investigation is needed to bring studies on miRNAs and lncRNAsinto clinical practice for diagnosis, prognosis, and therapeutics in breast cancer patients	30545127	2018	Circular RNA hsa_circ_0001982 promotes breast cancer cell carcinogenesis through decreasing miR-143	0	0	1	94
chr6	135621637	135644462	-	AHI1	hsa_circ_0005214	Microarray,qRT-PCR,luciferase assay,etc.	Up	In summary, our study verifies the circRNA expressionprofiles using microarray analysis and uncovers hsa_circhsa_circ_0001982 to explore its physiological function, providinga novel perspective on the biogenesis, biological function,oncogenesis, progression, and possible therapies for breastcancer involving circRNAs.	28933584	2017	Circular RNA hsa_circ_0001982 Promotes Breast CancerCell Carcinogenesis Through Decreasing miR-143	0	0	0	95
chr6	135621637	135644462	-	AHI1	hsa_circ_0005214	Microarray,qRT-PCR,luciferase assay,etc.	Up	ncRNAs are dysregulated in breast cancer and miRNAs, noted for their stability, and lncRNAs arebeing investigated as biomarkers of disease pathology, prognostic indicators, and potential therapeutictargets, as well as modalities to block cancer progression and metastasis. We know much moreabout miRNAs than lncRNAs in human breast tumors. Our understanding of the networks betweenmiRNAs, lncRNAs, their interacting partners, and targets is expanding. However, individual andcombinations of miRNAs and lncRNAs have cell-specific activities that are not fully understood,nor is their interaction with the immune system, microbiome, microenvironment, hormonal milieu,or metabolome elucidated. Further investigation is needed to bring studies on miRNAs and lncRNAsinto clinical practice for diagnosis, prognosis, and therapeutics in breast cancer patients	30545127	2018	Circular RNA hsa_circ_0001982 promotes breast cancer cell carcinogenesis through decreasing miR-143	0	0	1	96
chr10	117849251	117856275	-	GFRA1	hsa_circ_0005239 	Microarray,qRT-PCR,Luciferase assay,RIP,Western blot,etc.	up	Taken together, our study indicates that circGFRA1 isupregulated and correlated with poor clinical outcomes inTNBC. circGFRA1 could promote proliferation and inhibitapoptosis in TNBC. And circGFRA1 functions as aceRNA to regulate GFRA1 expression by decoyingmiR-34a in TNBC progression. circGFRA1 can beused as a diagnostic biomarker and potential target inTNBC therapy.	29037220	2017	circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a	0	0	1	97
chr12	66597490	66622150	+	IRAK3	hsa_circ_0005505 	Microarray,qRT-PCR,FISH,Luciferase assay,Western blot,RNAi,etc.	up	Results: Microarray analysis and qRT-PCR verified a circRNA termed circGFRA1 that was upregulated in TNBC. Kaplan-Meier survival analysis showed that upregulated circGFRA1 was correlated with poorer survival. Knockdown of circGFRA1 inhibited proliferation and promoted apoptosis in TNBC. Via luciferase reporter assays, circGFRA1 and GFRA1 was observed to directly bind to miR-34a. Subsequent experiments showed that circGFRA1 and GFRA1 regulated the expression of each other by sponging miR-34a.Conclusions: Taken together, we conclude that circGFRA1 may function as a competing endogenous RNA (ceRNA) to regulate GFRA1 expression through sponging miR-34a to exert regulatory functions in TNBC. circGFRA1 may be a diagnostic biomarker and potential target for TNBC therapy. 	29803789	2018	CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis	0	1	1	98
chr15	28482108	28508315	-	HERC2	hsa_circ_0006147	Microarray,qRT-PCR,luciferase assay,etc.	Down	ncRNAs are dysregulated in breast cancer and miRNAs, noted for their stability, and lncRNAs arebeing investigated as biomarkers of disease pathology, prognostic indicators, and potential therapeutictargets, as well as modalities to block cancer progression and metastasis. We know much moreabout miRNAs than lncRNAs in human breast tumors. Our understanding of the networks betweenmiRNAs, lncRNAs, their interacting partners, and targets is expanding. However, individual andcombinations of miRNAs and lncRNAs have cell-specific activities that are not fully understood,nor is their interaction with the immune system, microbiome, microenvironment, hormonal milieu,or metabolome elucidated. Further investigation is needed to bring studies on miRNAs and lncRNAsinto clinical practice for diagnosis, prognosis, and therapeutics in breast cancer patients	30545127	2018	Circular RNA hsa_circ_0001982 promotes breast cancer cell carcinogenesis through decreasing miR-143	0	0	1	99
chr17	35800605	35800763	+	TADA2A	hsa_circ_0006220 	qRT-PCR,etc.	Down?	In summary, by using circRNA screening and functional verification together with clinical evidence, our study demonstrated the potential of two circTADA2As as promising prognostic biomarkers for breast cancer. Especially, circTADA2A-E6 functioned as a tumor suppressor by inhibiting cell proliferation, migration, and metastasis in breast cancer. Mechanistically, circTADA2A-E6 acted as a miR-203a-3p sponge restoring the expression of the miR-203a-3p target gene SOCS3. To the best of our knowledge, this is the first report thoroughly investigating the biological functions of circTADA2As and their clinical implications in breast cancer. This study may have a fundamental influence on breast cancer research, particularly for the identification of new biomarkers and future therapeutic targets paving the way for new pharmaceutical interventions for breast cancer.	30787278	2018	circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis	1	0	1	100
chr5	145197456	145205763	-	PRELID2	hsa_circ_0006528	qRT-PCR,Western Blot,etc.	up	In conclusion, our present study analyzed the expression of circRNAs in chemoresistant breast cancer; we revealedthat circRNAs may play a role in breast cancer chemoresistance, andcirc0006528might be a worthy candidatefor further verification and functional analysis.	28803498	2017	Screening circular RNA related to chemotherapeutic resistance in breast cancer	0	0	1	101
NA	NA	NA	NA	NA	hsa_circ_0007294?	qRT-PCR,Luciferase assay,etc.	up	Conclusions:Our data uncover an essential role of the novel circular RNA circANKS1B in the metastasis ofbreast cancer, which demonstrate that therapeutic targeting of circANKS1B may better prevent breast cancermetastasis.	30454010	2018	The pro-metastasis effect of circANKS1B in breast cancer	0	0	1	102
chr17	61869771	61877977	+	DDX42	hsa_circ_0007534	qRT-PCR,Western blot,RNAi,etc.	Down?	In conclusion, knockdown of hsa_circ_0007534 can significantlysuppress BC progression by reducing miR-593 to promote MUC19production.	30139516	2018	Downregulation of hsa_circ_0007534 suppresses breast cancer cell proliferation and invasion by targeting miR-593/MUC19 signal pathway.	0	0	1	103
chr7	716865	751164	-	PRKAR1B	hsa_circ_0008039	etc.	differential expression	In summary, a large number of circRNAs, in-cluding circ_ANKS1B, circ_AGFG1, circ_IRAK3, circ_GFRA1 and circ_EPSTI1, show great po-tential to function in carcinogenesis, metasta-sis or chemoresistance of breast cancer via transcriptional regulation of RNAs including mi-RNA and mRNA, in addition to their promise as stable biomarkers that can be used for moni-toring breast cancer progression. The oncogen-ic or anti-oncogenic roles of circRNAs can be utilized in the treatment and prognosis of br-east cancer. However, the translation phenom-enon of circRNAs in breast cancer and the di-agnostic value of circRNAs in breast cancer requires further investigation for which the de-tection of circRNAs in plasma exosomes could be worthy of trying. Moreover, engineered exo-somes preloaded with engineered anti-onco-genic circRNAs may are likely to provide a novel direction in the personal medicine of breast cancer.	29807010	2019	Circular RNA hsa_circ_0008039 promotes br-east cancer cell proliferation and migration by regulating  miR-432-5p/E2F3  axis.  Bioch-emi-cal and Biophysical Research Communications	0	1	1	104
chr7	716865	751164	-	PRKAR1B	hsa_circ_0008039	qRT-PCR,Luciferase assay,etc.	up	In summary, our study for thefirst time investigated the role ofhsa_circ_0008039 and identified it as an oncogene in breast cancer.Ourfindings demonstrated hsa_circ_0008039 contributes to breastcancer progression via enhancing E2F3 expression by spongingmiR-432-5p, suggesting hsa_circ_0008039 might be a potentialtarget for breast cancer therapy.	29807010	2018	Circular RNA hsa_circ_0008039 promotes breast cancer cell proliferation and migration by regulating miR-432-5p/E2F3 axis.	0	0	1	105
chr1	229665945	229678118	-	ABCB10	hsa_circ_0008717	qRT-PCR,microarray,Luciferase assay,etc.	up	The differences in circRNA expression in breast cancer tissue are associated with diverse pathogenesis. The present study identified circ-ABCB10 in breast cancer tissue, and its role in acting as a miR-1271 sponge. In summary, the role of circ-ABCB10 in breast cancer carcinogenesis via sponging miR-1271 provides a novel insight for therapy and prevention in breast cancer.	28744405	2017	Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271	0	0	1	106
chr1	22155875	22166510	-	HSPG2	hsa_circ_0010567	Microarray,qRT-PCR,luciferase assay,etc.	Up	In summary, our study verifies the circRNA expressionprofiles using microarray analysis and uncovers hsa_circhsa_circ_0001982 to explore its physiological function, providinga novel perspective on the biogenesis, biological function,oncogenesis, progression, and possible therapies for breastcancer involving circRNAs.	28933584	2017	Circular RNA hsa_circ_0001982 Promotes Breast CancerCell Carcinogenesis Through Decreasing miR-143	0	0	0	107
chr1	41578954	41618413	-	SCMH1	hsa_circ_0011946	qRT-PCR,Western Blot,etc.	up	Taken together, these circRNA expression profile findings from high-throughput RNA sequencing technology showed 152 circRNAs changing remarkably in breast cancer tissues and the preliminarily determined hsa_circ_0011946 being a key regulator of breast cancer. The outcome of the biomath-ematical prediction and in vitro experiments manifested that the inactivation of the hsa_circ_0011946/RFC3 signaling pathway could inhibit the migration and invasion capacities of MCF-7 cells	29593432	2018	Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3.	0	0	0	108
NA	NA	NA	NA	NA	hsa_circ_0011946?	RT-qPCR,Western blot,etc.	up	In the present study, we utilized high-throughput sequencing and experimental validation in vitro to uncover the differentially expressed circRNAs in breast cancer tissues and cell lines and found that hsa_circ_0011946 was significantly upregulated. Moreover, a bioinformatics analysis showed RFC3 to be a target gene of hsa_circ_0011946. Furthermore, we downregulated hsa_circ_0011946 in the Michigan Cancer Foundation-7 (MCF-7) cell line and performed cell proliferation, migration, and invasion experiments, in order to elaborate on its function.	29593432	2018	Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3	0	0	0	109
chr1	47761436	47778693	-	STIL	hsa_circ_0012380	Microarray,qRT-PCR,luciferase assay,etc.	Up	In summary, our study verifies the circRNA expressionprofiles using microarray analysis and uncovers hsa_circhsa_circ_0001982 to explore its physiological function, providinga novel perspective on the biogenesis, biological function,oncogenesis, progression, and possible therapies for breastcancer involving circRNAs.	28933584	2017	Circular RNA hsa_circ_0001982 Promotes Breast CancerCell Carcinogenesis Through Decreasing miR-143	0	0	0	110
chr1	175916330	176105683	-	RFWD2	hsa_circ_0015350	Microarray,qRT-PCR,luciferase assay,etc.	Up	In summary, our study verifies the circRNA expressionprofiles using microarray analysis and uncovers hsa_circhsa_circ_0001982 to explore its physiological function, providinga novel perspective on the biogenesis, biological function,oncogenesis, progression, and possible therapies for breastcancer involving circRNAs.	28933584	2017	Circular RNA hsa_circ_0001982 Promotes Breast CancerCell Carcinogenesis Through Decreasing miR-143	0	0	0	111
NA	NA	NA	NA	NA	hsa_circ_001569	qRT-PCR,Western Blot,etc.	up	In summary, our study firstly provided evidence413that hsa_circ_001569 upregulation was closely asso-414ciated with BC lymph-node metastasis and clinical415stage, and may be an independent risk factor for416poor prognosis. Additionally, our results indicated that417hsa_circ_001569 may contribute to progression of BC418by modulating PI3K-AKT pathway. These results sug-419gest that hsa_circ_001569 may be a target for BC ther-420apy in the future.	31104012	2019	Hsa_circ_001569 is an unfavorable prognostic factor and promotes cell proliferation and metastasis by modulating PI3K-AKT pathway in breast cancer.	0	0	1	112
NA	NA	NA	NA	NA	hsa_circ_001783	FISH,RIP,Luciferase assay,etc.	down	In summary, we have proposed a comprehensivemethod to systematically screen breast cancer specificcircular RNAs through integrating an in silico pipelinewith in vitro and ex vivo techniques. We highlighted thathsa_circ_001783 as a novel prognostic marker for breastcancer and uncovered its new mechanism in regulat-ing cancer proliferation and metastasis via sponging miR-200c-3p. Thus, this circular RNA might be a potentialtherapeutic target for breast cancer treatment.	30670688	2019	Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p.	0	0	1	113
chr12	120995084	120995485	+	RNF10	hsa_circ_0028899	etc.	Down	We successfully established a ceRNA network to describe thepossible mechanisms of breast cancer, which can shed light on thecircRNA-related ceRNA network in breast cancer. The currentstudy shows that hsa_circ_0000519 may play important roles inbreast cancer. Thesefindings may provide potential biomarkersor therapeutic targets for breast cancer patien	31725681	2019	Identification of breast cancer-related circRNAs by analysis of microarray and RNA-sequencing data: An observational study.	0	1	1	114
chr19	53158813	53164096	-	ZNF83	hsa_circ_0052112	qRT-PCR,luciferase assay,FISH,etc.	up	In summary, our study revealed that hsa_circ_0052112 was up-regulated in MDA-MB-231 cells, and overexpression of hsa_-circ_0052112 contributed to the migration and invasion of breastcancer cells by functioning as a sponge for miR-125a-5p. Althoughexploring the potential clinicopathological significance of hsa_-circ_0052112 in breast cancer tissues remains insufficient, our resultssuggest hsa_circ_0052112 may serve as a novel biomarker and provide apotent therapeutic target of breast cancer.	30257349	2018	Circular RNA hsa_circ_0052112 promotes cell migration and invasion by acting as sponge for miR-125a-5p in breast cancer.	0	0	1	115
NA	NA	NA	NA	NA	hsa_circ_006054	qRT-PCR,microarray,etc.	Down	In summary, our study provided a profile of circRNAs in breast cancer and adjacent normal-appearing tissues. We discovered that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 were upregulated, while hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated in breast cancer tissues. Specific circRNAs are important promoters of carcinogenesis, as they participate in cancer-related pathways and sequester miRNAs, and thus may be useful biomarkers of breast cancer.	28484086	2017	dentification of circular RNAsas a promising new class of diagnostic biomarkers for human breast cancer	0	0	1	116
NA	NA	NA	NA	NA	hsa_circ_006054	microarray,qRT-PCR,etc.	Down?	In summary, our study provided a profile of circRNAs in breast cancer and adjacent normal-appearing tissues. We discovered that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 were upregulated, while hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated in breast cancer tissues. Specific circRNAs are important promoters of carcinogenesis, as they participate in cancer-related pathways and sequester miRNAs, and thus may be useful biomarkers of breast cancer.	28484086	2017	Identification of Circular RNAs as a Promising New Class of Diagnostic Biomarkers for Human Breast Cancer	0	1	0	117
chr21	43782390	43786644	-	TFF1	hsa_circ_0061825	qRT-PCR,Western blot,FISH,RIP,Luciferase assay,etc.	Down?	In summary, this investigation proved that circ\TFF1, which derived from the host gene TFF1, elicited an oncogenic function in breast cancer by freeing TFF1 from miR\326\induced silence (Figure 7G). The link between the modulatory mechanism of circ\TFF1\miR\326\TFF1 axis and cellular activities in breast cancer is revealed here for the first time, and our findings will offer a novel insight into the therapy of breast cancer patients. 	31961997	2020	Circular RNA hsa_circ_0061825 (circ-TFF1) contributes to breast cancer progression through targeting miR-326/TFF1 signalling.	0	0	1	118
chr3	175165016	175455187	+	NAALADL2	hsa_circ_0068033	qRT-PCR,microarray,etc.	down	In conclusion, our study reveals that multiple circRNAs are closely correlatedwith breast cancer tumorigenesis, and thoroughlyinvestigates the diagnostic valueof hsa_circ_0001785, suggesting the promisingbiomarker for breast cancerdetection.	29045858	2018	Circulating circularRNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancerdetection	0	1	1	119
NA	NA	NA	NA	NA	hsa_circ_0072309	luciferase assay,qRT-PCR,etc.	down	Results: hsa_circ_0072309 expression in breast cancer tissues was upregulated relative to that in adjacent normal tissues. hsa_circ_0072309 could serve as a prognostic biomarker of breast cancer. hsa_circ_0072309 overexpression dramatically inhibited the proliferation, migration, and invasion of breast cancer cells in vitro. In vivo assays revealed that the ectopic expression of hsa_circ_0072309 repressed breast cancer growth. The results of our mechanistic studies indicated that hsa_circ_0072309 could act as the sponge of miR-492, which exhibited increased expression in breast cancer tissues. Hsa_circ_0072309 suppressed breast cancer cell proliferation, migration, and invasion by inhibiting miR-492.Conclusion: Our findings revealed for the first time that the hsa_circ_0072309-miR-492 axis plays an essential role in breast cancer progression. 	30774431	2019	Circular RNA hsa_circ_0072309 Inhibits Proliferation and Invasion of Breast Cancer Cells via Targeting miR-492	0	0	1	120
chr5	38523520	38530768	-	LIFR	hsa_circ_0072309	luciferase assays,qRT-PCR,etc.	down	Our findings revealed for the first time that the hsa_circ_0072309-miR-492 axis plays an essential role in breast cancer progression.	30774431	2019	Circular RNA hsa_circ_0072309 inhibits proliferation and invasion of breast cancer cells via targeting miR-492.	0	0	1	121
chr5	73069679	73076570	+	RGNEF	hsa_circ_0072995	qRT-PCR,Luciferase assay,etc.	up	In summary, our study revealed that hsacirc0072995 was upregulated in MDA-MB-231 cells compared withMCF-7 cells, and overexpression of hsacirc0072995 promoted breast cancer cells migration and invasion by directsponge for miR-30c-2-3p. Nonetheless, conducting migration and invasion experiments in multiple breast cancercell lines, tissues or animals remains insufficient. Despite this, our results suggest that hsacirc0072995 may serveas a novel biomarker, and studying the molecular mechanisms by which circRNAs act as miRNA sponges mayrepresent a new direction to regulate the development of breast cancer	30182731	2018	Circular RNA hsa_circ_0072995 promotes breast cancer cell migration and invasion through sponge for miR-30c-2-3p.	0	0	1	122
chr18	9182379	9200642	+	ANKRD12	hsa_circ_0108942	qRT-PCR,microarray,etc.	up	In conclusion, our study reveals that multiple circRNAs are closely correlatedwith breast cancer tumorigenesis, and thoroughlyinvestigates the diagnostic valueof hsa_circ_0001785, suggesting the promisingbiomarker for breast cancerdetection.	29045858	2018	Circulating circularRNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancerdetection	0	1	1	123
chr18	9182379	9200642	+	ANKRD12	hsa_circ_0108942	microarray,qRT-PCR,etc.	up	In conclusion, our study reveals that multiple circRNAs are closely correlatedwith breast cancer tumorigenesis, and thoroughlyinvestigates the diagnostic valueof hsa_circ_0001785, suggesting the promisingbiomarker for breast cancerdetection.	29045858	2018	Circulating circular RNA hsa_circ_0001785 acts as a diagnosticbiomarker for breast cancer detection.	0	1	1	124
chr8	48715866	48730122	-	PRKDC	hsa_circ_0136666 	qRT-PCR,Western blot,Luciferase assay	up	Taken these together, our data implied that hsa_-circ_0136666/miR\1299/CDK6 axis was involved inbreast cancer and hsa_circ_0136666 is provided as asignificant biomarker for breast cancer treatment	30993801	2019	Upregulation of hsa_circ_0136666 contributes to breast cancer progression by sponging miR-1299 and targeting CDK6.	0	0	1	125
chr14	97312431	97327072	+	VRK1	hsa_circ_0141206 	Western blot,etc.	Down?	In conclusion, the current work was the first to indicate the circRNA signature of BCSCs. We determined the circRNA/miRNA network and analysed the potential functional roles of dysregulated circRNAs. Furthermore, we revealed that circVRK1 was capable to negatively regulate the stemness of BCSCs. Our findings strengthen the possibility that circVRK1 is able to serve as a potential target for BCSCs. Additionally, the current data also provide supports for further study on circRNAs in stemness maintenance of BCSCs.	29221160	2017	Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells	0	0	0	126
NA	NA	NA	NA	NA	hsa_circ_100219	qRT-PCR,microarray,etc.	Down	In summary, our study provided a profile of circRNAs in breast cancer and adjacent normal-appearing tissues. We discovered that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 were upregulated, while hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated in breast cancer tissues. Specific circRNAs are important promoters of carcinogenesis, as they participate in cancer-related pathways and sequester miRNAs, and thus may be useful biomarkers of breast cancer.	28484086	2017	dentification of circular RNAsas a promising new class of diagnostic biomarkers for human breast cancer	0	0	1	127
NA	NA	NA	NA	NA	hsa_circ_100219	microarray,qRT-PCR,etc.	Down?	In summary, our study provided a profile of circRNAs in breast cancer and adjacent normal-appearing tissues. We discovered that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 were upregulated, while hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated in breast cancer tissues. Specific circRNAs are important promoters of carcinogenesis, as they participate in cancer-related pathways and sequester miRNAs, and thus may be useful biomarkers of breast cancer.	28484086	2017	Identification of Circular RNAs as a Promising New Class of Diagnostic Biomarkers for Human Breast Cancer	0	1	0	128
NA	NA	NA	NA	NA	hsa_circ_103110	microarray,qRT-PCR,etc.	up	In summary, our study provided a profile of circRNAs in breast cancer and adjacent normal-appearing tissues. We discovered that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 were upregulated, while hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated in breast cancer tissues. Specific circRNAs are important promoters of carcinogenesis, as they participate in cancer-related pathways and sequester miRNAs, and thus may be useful biomarkers of breast cancer.	28484086	2017	Identification of Circular RNAs as a Promising New Class of Diagnostic Biomarkers for Human Breast Cancer	0	1	0	129
NA	NA	NA	NA	NA	hsa_circ_104689	qRT-PCR,microarray,etc.	up	In summary, our study provided a profile of circRNAs in breast cancer and adjacent normal-appearing tissues. We discovered that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 were upregulated, while hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated in breast cancer tissues. Specific circRNAs are important promoters of carcinogenesis, as they participate in cancer-related pathways and sequester miRNAs, and thus may be useful biomarkers of breast cancer.	28484086	2017	dentification of circular RNAsas a promising new class of diagnostic biomarkers for human breast cancer	0	0	1	130
NA	NA	NA	NA	NA	hsa_circ_104689	microarray,qRT-PCR,etc.	up	In summary, our study provided a profile of circRNAs in breast cancer and adjacent normal-appearing tissues. We discovered that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 were upregulated, while hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated in breast cancer tissues. Specific circRNAs are important promoters of carcinogenesis, as they participate in cancer-related pathways and sequester miRNAs, and thus may be useful biomarkers of breast cancer.	28484086	2017	Identification of Circular RNAs as a Promising New Class of Diagnostic Biomarkers for Human Breast Cancer	0	1	0	131
NA	NA	NA	NA	NA	hsa_circ_104821	qRT-PCR,microarray,etc.	up	In summary, our study provided a profile of circRNAs in breast cancer and adjacent normal-appearing tissues. We discovered that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 were upregulated, while hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated in breast cancer tissues. Specific circRNAs are important promoters of carcinogenesis, as they participate in cancer-related pathways and sequester miRNAs, and thus may be useful biomarkers of breast cancer.	28484086	2017	dentification of circular RNAsas a promising new class of diagnostic biomarkers for human breast cancer	0	0	1	132
NA	NA	NA	NA	NA	hsa_circ_104821	microarray,qRT-PCR,etc.	up	In summary, our study provided a profile of circRNAs in breast cancer and adjacent normal-appearing tissues. We discovered that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 were upregulated, while hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated in breast cancer tissues. Specific circRNAs are important promoters of carcinogenesis, as they participate in cancer-related pathways and sequester miRNAs, and thus may be useful biomarkers of breast cancer.	28484086	2017	Identification of Circular RNAs as a Promising New Class of Diagnostic Biomarkers for Human Breast Cancer	0	1	0	133
NA	NA	NA	NA	NA	hsa_circ_406697	qRT-PCR,microarray,etc.	Down	In summary, our study provided a profile of circRNAs in breast cancer and adjacent normal-appearing tissues. We discovered that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 were upregulated, while hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated in breast cancer tissues. Specific circRNAs are important promoters of carcinogenesis, as they participate in cancer-related pathways and sequester miRNAs, and thus may be useful biomarkers of breast cancer.	28484086	2017	dentification of circular RNAsas a promising new class of diagnostic biomarkers for human breast cancer	0	0	1	134
NA	NA	NA	NA	NA	hsa_circ_406697	microarray,qRT-PCR,etc.	Down?	In summary, our study provided a profile of circRNAs in breast cancer and adjacent normal-appearing tissues. We discovered that hsa_circ_103110, hsa_circ_104689 and hsa_circ_104821 were upregulated, while hsa_circ_006054, hsa_circ_100219 and hsa_circ_406697 were downregulated in breast cancer tissues. Specific circRNAs are important promoters of carcinogenesis, as they participate in cancer-related pathways and sequester miRNAs, and thus may be useful biomarkers of breast cancer.	28484086	2017	Identification of Circular RNAs as a Promising New Class of Diagnostic Biomarkers for Human Breast Cancer	0	1	0	135
chr5	145197456	145205763	-	PRELID2	hsa_circ_0006528	qRT-PCR,luciferase assay,Western Blot,etc.	up	As an emerging key player in the RNA world, circRNAs may widely affect life processes and various diseases, especially cancers. Based on our research results, we conclude that circ_0006528 was significantly upregulated in human breast cancer tissues and that aberrant circ_0006528 expression was significantly associated with advanced TNM stage and poor prognosis. Furthermore, circ_0006528 through the circ_0006528/miR-7-5p/Raf1/MAPK/ERK signalling pathway mediates the growth and metastasis of breast cancer, which provides theoretical and experimental insight into the role of circ_0006528 in breast cancer tumourigenesis and metastasis. Thus, circ_0006528 may serve as a biomarker for predicting prognosis and could be a new therapeutic target in targeted therapy for breast cancer. 	30520151	2019	hsa_circRNA_0006528 as a competing endogenous RNA promotes human breast cancer progression by sponging miR-7-5p and activating the MAPK/ERK signaling pathway.	1	0	1	136
NA	NA	NA	NA	NA	hsa_circ_002178	FISH,Microarray,Western blot,etc.	Down?	In this regard, we hypothesized that hsa_circRNA_002178 might regulate the behaviours of breast cancer cells through interacting with in miR\328\3p and COL1A1. Both in vitro and in vivo experiments were designed to characterize the role of hsa_circRNA_002178 and further identify the detailed interactions with miR\328\3p and COL1A1. 	31957232	2020	Circular RNA hsa_circRNA_002178 silencing retards breast cancer progression via microRNA-328-3p-mediated inhibition of COL1A1.	0	0	1	137
