chr9	4860642	4860643	+	NULL	miR-101-2	rs1053872	flanking region of pre-miRNA 	C/G	C	genotyping	blood tissue	NULL	Chinese	case:1064, control:1073	NULL	NULL	24475105	Genetic Variations in the Flanking Regions of miR-101-2 Are Associated with Increased Risk of Breast Cancer	The SNPs rs462480 residing in miR-101-2 gene may have a solid impact on genetic susceptibility to breast cancer.
chr9	4850435	4850436	-	NULL	miR-101-2	rs462480	flanking region of pre-miRNA 	A/C	A	genotyping	blood tissue	NULL	Chinese	case:1064, control:1073	NULL	NULL	24475105	Genetic Variations in the Flanking Regions of miR-101-2 Are Associated with Increased Risk of Breast Cancer	The SNPs rs1053872 residing in miR-101-2 gene may have a solid impact on genetic susceptibility to breast cancer.
chr22	20111020	20111021	+	DGCRB	miR-106b	rs417309	3'utr	G/A	G	SNP selection/genotyping/luciferase reporter plasmid/transient transfections and luciferase assay	blood tissue	decrease	Chinese women	case:1761, control:1853	A=0.0462	A=0.0318	23629745	Evaluation of genetic variants in microRNA biosynthesis genes and risk of breast cancer in Chinese women	SNP (rs417309) located in the 3'-UTR of DGCR8 was consistently associated with an increased breast cancer risk in two stages with a combined odds ratio (OR) of 1.50. DGCR8 rs417309 G>A may increase the risk of breast cancer through interrupting miRNA-106b or miRNA-579 binding affinity.
chr4	95154813	95154814	-	BMPR1B	miR-125b	rs1434536	3'utr	C/T	G	genotyping and quality control/cell lines,cloning and dual luciferase reporter assay/transfection and RT-qPCR	blood tissue	decrease	NULL	case:428, control:1064	C=0.4024	C=0.4459	19738052	A risk variant in a miR-125b binding site in BMPR1B is associated with breast cancer pathogenesis	rs1434536 C>T alleles reduced binding of miR-125b to BMPR1B. rs1434536-T results in increased BMPR1B transcript.These results suggest that allele-specific regulation of BMPR1B by miR-125b explains the observed disease risk. Our approach is general and can help identify and explain the mechanisms behind disease association for alleles that affect miRNA regulation.
chr2	211377466	211377467	+	ErbB4	miR-1276	rs11895168	3'utr	A/C	A	genotyping	blood tissue	NULL	Iranian	case:172, control:192	C=0.1279	C=0	27262100	rs11895168 C allele and the increased risk of breast cancer in Isfahan population	Rs11895168 affect the binding strength of miR-1276, a potential tumor suppressor. Statistical analysis showed a significant association between rs11895168 C allele-harboring genotypes and increased breast cancer risk.
chr3	169364844	169364845	+	EVI-1	miR-133b	rs6774494	3'utr	G/A	A	genotyping/western blot/RNA extraction and real-time PCR/cell proliferation,apoptosis assay,migration and invasion assays	blood tissue, cell lines( BC and MCF-7 )	NULL	Chinese	case:196, control:200	G=0.4438	G=0.4353	24935473	Correlations of common polymorphism of EVI-1 gene targeted by miRNA-206/133b with the pathogenesis of breast cancer	EVI-1 mRNA levels were negatively associated with miRNA-133b levels in the carriers of the G allele. The EVI-1 rs6774494 G>A polymorphism targeted by miRNA-133b may contribute to the pathogenesis of BC.
chr5	160485410	160485411	+	NULL	miR-146a	rs2910164	pre-miRNA	G/C	G	genotyping	blood tissue	NULL	Indian	case:121, control:164	C=0.1777	C=0.2683	25374621	Common genetic variants in pre-microRNAs and risk of breast cancer in the North Indian population	The heterozygous variant of miR-146a G/C (rs2910164) is associated with the reduced risk of breast cancer at the genotype level as well as at the allele level as compared to controls. The results of the present study demonstrate that miR-146a G/C (rs2910164) polymorphism is associated with reduced genetic susceptibility to breast cancer.
chr5	160485410	160485411	+	NULL	miR-146a	rs2910164	unspecified miRNA	G/C	G	genotyping	BC tissue	NULL	Caucasian Australian	case:546, control:246	C=0.2280	C=0.3434	26476291	Association of the microRNA-Single Nucleotide Polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study	The presence of the G allele of rs2910164 is associated with increased cancer risk. The microRNA miR146a has a potential role in the development of breast cancer and the effects of its SNPs require further inquiry to determine the nature of their influence on breast tissue and cancer.
chr4	168928237	168928238	+	PALLD	miR-182	rs1071738	3'utr	C/G	C	dual luciferase reporter assay/western blot/ 	HEK-293T, HeLa, Hs578, MCF-7 and T47D cell lines	NULL	NULL	NULL	NULL	NULL	27641360	Local microRNA delivery targets Palladin and prevents metastatic breast cancer	miR-182 downregulate Palladin protein levels, thereby reducing breast cancer cell migration and invasion. A common SNP, rs1071738, at the miR-182-binding site within the Palladin 3'-UTR abolishes miRNA:mRNA binding, thus diminishing Palladin regulation by these miRNAs. Our data corroborate the role of miRNAs in metastasis, and suggest miR-96/miR-182 delivery as a potential anti-metastatic drug.
chr22	20032705	20032706	+	NULL	miR-185	rs2008591	pre-miRNA	T/C	C	genotyping	blood tissue	NULL	NULL	NULL	NULL	NULL	23526039	Association of germline microRNA SNPs in pre-miRNA flanking region and breast cancer risk and survival: the Carolina Breast Cancer Study	The miR-185 SNP provided suggestive evidence of an inverse association with breast cancer risk.Our results suggest that germline variation in the 5' region proximal to pre-miRNA gene sequences may be associated with breast cancer risk among African Americans and breast cancer-specific survival generally; however, further validation is needed to confirm these findings.
chr22	20032549	20032550	+	NULL	miR-185	rs887205	pre-miRNA	A/G	A	genotyping	blood tissue	NULL	NULL	NULL	NULL	NULL	23526039	Association of germline microRNA SNPs in pre-miRNA flanking region and breast cancer risk and survival: the Carolina Breast Cancer Study	The miR-185 SNP provided suggestive evidence of an inverse association with breast cancer risk.Our results suggest that germline variation in the 5' region proximal to pre-miRNA gene sequences may be associated with breast cancer risk among African Americans and breast cancer-specific survival generally; however, further validation is needed to confirm these findings.
chr12	53991814	53991815	+	NULL	miR-196a	rs11614913	unspecified miRNA	T/C	C	genotyping	breast tissue 	NULL	Korean	case:450, control:0	C=0.454	NULL	24922658	Genetic Polymorphism of miR-196a as a Prognostic Biomarker for Early Breast Cancer	The C allele of miR-196a rs11614913 T>C was significantly associated with worse disease-free (DFS) and distant DFS (DDFS). The current study provides evidence that the miR-196a rs11614913T>C polymorphisms are possible prognostic biomarker for patients with hormone receptor-expressing early breast cancer.
chr12	53991814	53991815	+	NULL	miR-196a2	rs11614913	pre-miRNA	T/C	C	SNP selection and genotyping	blood tissue	NULL	Chinese women	case:1009, control:1093	C=0.4762	C=0.4254	18634034	Common Genetic Variants in Pre-MicroRNAs Were Associated With Increased Risk of Breast Cancer in Chinese Women	hsa-mir-196a2 rs11614913 T>C  variant genotypes were associated with significantly increased risks of breast cancer.These findings suggest, for the first time, that common SNPs in miRNAs may contribute to breast cancer susceptibility.
chr12	53991814	53991815	+	NULL	miR-196a2	rs11614913	pre-miRNA	C/T	C	SNP identification and genotyping/RNA isolation and miRNA detection	blood tissue, breast adenocarcinoma cells (MCF-7)	NULL	NULL	case:426, control:466	T=0.3298	T=0.398	19567675	MicroRNA miR-196a-2 and breast cancer: a genetic and epigenetic association study and functional analysis	Variant in hsa-miR-196a-2 (rs11614913,C>T) was significantly associated with decreased breast cancer risk. This variant led to less efficient processing of the miRNA precursor to its mature form, as well as diminished capacity to regulate target genes.
chr12	53991814	53991815	+	NULL	miR-196a2	rs11614913	pre-miRNA	C/T	C	genotyping	blood tissue	NULL	Brazilian women	case:388, control:388	T=0.46	C=0.4073	23228090	Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer	The CC polymorphic genotype is associated with a decreased risk of breast cancer and the presence of the T allele was significantly associated with an increased risk of breast cancer.
chr12	53991814	53991815	+	NULL	miR-196a2	rs11614913	unspecified miRNA	T/C	C	real-time PCR	cell lines(BT-549, HCC1806, Hs578T, MCF7, MDA-MB-231, SW527, T-47D, and ZR-75-1), BC tissue 	increase	Chinese	case:114, control:114	T=0.4912	T=0.4868	26710106	Somatic Mutation of the SNP rs11614913 and Its Association with Increased MIR 196A2 Expression in Breast Cancer	The expression level of mature MIR 196A2 was highly elevated in breast cancers. The mutation state of SNP rs11614913 was statistically significantly associated with the higher expression level of mature MIR 196A2 in the tumors.
chr6	52143817	52143818	+	NULL	miR-206	rs6920648	pre-miRNA	G/A	A	genotyping	blood tissue	NULL	NULL	NULL	NULL	NULL	23526039	Association of germline microRNA SNPs in pre-miRNA flanking region and breast cancer risk and survival: the Carolina Breast Cancer Study	The miR-206 SNP provided evidence of association with breast cancer survival.Our results suggest that germline variation in the 5' region proximal to pre-miRNA gene sequences may be associated with breast cancer risk among African Americans and breast cancer-specific survival generally; however, further validation is needed to confirm these findings.
chr3	169364844	169364845	+	EVI-1	miR-206	rs6774494	3'utr	G/A	A	genotyping/western blot/RNA extraction and real-time PCR/cell proliferation,apoptosis assay,migration and invasion assays	blood tissue, cell lines( BC and MCF-7 )	NULL	Chinese	case:196, control:200	G=0.4438	G=0.4353	24935473	Correlations of common polymorphism of EVI-1 gene targeted by miRNA-206/133b with the pathogenesis of breast cancer	EVI-1 mRNA levels were negatively associated with miRNA-206 levels in the carriers of the G allele. The EVI-1 rs6774494 G>A polymorphism targeted by miRNA-206 may contribute to the pathogenesis of BC.
chr19	13836477	13836478	+	NULL	miR-27a	rs895819	pre-miRNA	A/G	T	SNP verification and sequencing/genotyping	blood tissue	decrease	German women	case:1217, control:1422	G=0.3111	G=0.3396	19921425	A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk	The SNP rs895819, located in the terminal loop of pre-miRNA-27a, showed a protective effect. In a large familial breast cancer study cohort, the rare [G] allele of rs895819 was found to be less frequent in the cases than in the controls, indicating a reduced familial breast cancer risk. The G-variant of rs895819 might impair the maturation of the oncogenic miR-27a and thus, is associated with reduced familial breast cancer risk.
chr19	13836477	13836478	+	NULL	miR-27a	rs895819	pre-miRNA	A/G	T	DNA extraction/SNP genotyping analysis/RT-qPCR analysis/IHC and evaluation of IHC staining/statistics	blood tissue	decrease	Chinese	case:264, control:255	G=0.2424	G=0.2607	23954879	A genetic variant in pre-miR-27a is associated with a reduced breast cancer risk in younger Chinese population	The G allele of rs895819, which is correlated with reduced levels of miR-27a, was associated with reduced sporadic breast cancer risk among younger Chinese populations. Our results suggest that the SNP rs895819 may serve as a risk factor for breast cancer in younger Chinese populations; however, larger population-based studies are needed to validate these findings.
chr19	13836477	13836478	+	NULL	miR-27a	rs895819	pre-miRNA	A/G	T	genotyping	blood tissue	NULL	American	case:440, control:807	G=0.2545	G=0.2800	27421647	Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR-196a2, Pre-miR-423, miR-608 and Pre-miR-618 with breast cancer susceptibility in a South American population	The G/G genotype at rs895819:A > G (miR-27a) reduces BC risk in families with a moderate history of BC.
chr11	111511839	111511840	+	NULL	miR-34b	rs4938723	pre-miRNA	T/C	T	genotyping	blood tissue	NULL	NULL	NULL	NULL	NULL	23526039	Association of germline microRNA SNPs in pre-miRNA flanking region and breast cancer risk and survival: the Carolina Breast Cancer Study	The miR-34b SNP provided evidence of association with breast cancer survival.Our results suggest that germline variation in the 5' region proximal to pre-miRNA gene sequences may be associated with breast cancer risk among African Americans and breast cancer-specific survival generally; however, further validation is needed to confirm these findings.
chr11	111511839	111511840	+	NULL	miR-34c	rs4938723	pre-miRNA	T/C	T	genotyping	blood tissue	NULL	NULL	NULL	NULL	NULL	23526039	Association of germline microRNA SNPs in pre-miRNA flanking region and breast cancer risk and survival: the Carolina Breast Cancer Study	The miR-34c SNP provided evidence of association with breast cancer survival.Our results suggest that germline variation in the 5' region proximal to pre-miRNA gene sequences may be associated with breast cancer risk among African Americans and breast cancer-specific survival generally; however, further validation is needed to confirm these findings.
chr15	33866064	33866065	+	RYR3	miR-367	rs1044129	3'utr	A/G	A	RT-qPCR/immunofluorescence staining/thermodynamic model for the miRNA-target interaction/luciferase reporter gene assay/genotyping/immunohistochemistry	blood tissue , cell lines (MCF-7 and MDA-MB-231)	decrease	NULL	NULL	NULL	NULL	21810988	Functional SNP in the microRNA-367 binding site in the 3'UTR of the calcium channel ryanodine receptor gene 3 (RYR3) affects breast cancer risk and calcification	The results showed that compared with the AA genotype, G was a risk genotype for breast cancer development and was also associated with breast cancer calcification and poor survival. Thus, rs1044129 is a unique SNP that resides in a miRNA-gene regulatory loop that affects breast cancer risk, calcification, and survival.
chr3	119818049	119818050	+	PXR	miR-374a-3p	rs1054191	3'utr	C/T	G	sequencing	blood tissue	NULL	Indian	case:96, control:0	A=0.0266	NULL	27644647	Screening for the 3'UTR Polymorphism of the PXR Gene in South Indian Breast Cancer Patients and its Potential Role in Pharmacogenomics	Genetic variants identified in PXR 3' UTR and their effects on PXR levels through post-transcriptional regulation provide a genetic basis for inter-individual variability in treatment response and toxicity associated with chemotherapy.
chr17	30117164	30117165	+	NULL	miR-423	rs6505162	pre-miRNA	A/C	C	PCR	BC tissues	NULL	Caucasian women	case:179, control:174	C=0.3994	C=0.4712	22593246	A Genetic Variant Located in miR-423 is Associated with Reduced Breast Cancer Risk	The SNP in miR-423 is associated with reduced breast cancer risk.Analysis indicated that there were significant differences between the case and control populations, with the CC genotype conferring reduced risk of breast cancer development. Further functional research is required to determine the mechanism of action of this SNP on miRNA function.
chr17	30117164	30117165	+	NULL	miR-423	rs6505162	pre-miRNA	C/A	C	real-time RT-PCR/construction of expression vector	cell lines (BT-549, HCC1806, Hs578T, MCF7, MDA-MB-231, SW527, T-47D, ZR-75-1, SKBR3, 184A1, HBL100)	NULL	Chinese	case:114, control:189	A=0.1754	A=0.2354	25663458	Genetic analysis and preliminary function study of miR-423 in breast cancer	The SNP rs6505162 in pre-miR-423 affects the mature miR expression, and miR-423 plays a potentially oncogenic role in breast tumorigenesis.
chr17	30117164	30117165	+	NULL	miR-423	rs6505162	pre-miRNA	C/A	C	genotyping	blood tissue	NULL	American	case:440, control:807	A=0.4556	A=0.4095	27421647	Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR-196a2, Pre-miR-423, miR-608 and Pre-miR-618 with breast cancer susceptibility in a South American population	Rs6505162:C > A in pre-miR-423 increases risk of familial BC in families with a strong history of BC.
chr20	34990447	34990448	-	NULL	miR-499	rs3746444	pre-miRNA	A/G	T	SNP selection and genotyping	blood tissue	NULL	Chinese women	case:1009, control:1093	G=0.1714	G=0.1399	18634034	Common Genetic Variants in Pre-MicroRNAs Were Associated With Increased Risk of Breast Cancer in Chinese Women	hsa-mir-499 rs3746444 A>G variant genotypes were associated with significantly increased risks of breast cancer.These findings suggest, for the first time, that common SNPs in miRNAs may contribute to breast cancer susceptibility.
chr20	34990447	34990448	-	NULL	miR-499	rs3746444	unspecified miRNA	T/C	T	genotyping	breast tissues, blood tissue	NULL	Iranian	case:236, control:203	C=0.352	C=0.242	24521023	hsa-mir-499 rs3746444 gene polymorphism is associated with susceptibility to breast cancer in an Iranian population	Our study indicated that the hsa-mir-499 rs3746444 CC homozygote increased the risk of breast cancer in the dominant and recessive inheritance models tested. In addition, the rs3746444 C allele increased the risk of breast cancer in comparison with the T allele. The hsa-mir-499 rs3746444 polymorphism is associated with higher risk of developing breast cancer in our population.
chr3	119817733	119817734	+	PXR	miR-500a-3p	rs3732360	3'utr	C/T	C	sequencing	blood tissue	NULL	Indian	case:96, control:0	C=0.3882	NULL	27644647	Screening for the 3'UTR Polymorphism of the PXR Gene in South Indian Breast Cancer Patients and its Potential Role in Pharmacogenomics	Genetic variants identified in PXR 3' UTR and their effects on PXR levels through post-transcriptional regulation provide a genetic basis for inter-individual variability in treatment response and toxicity associated with chemotherapy.
chr15	98962598	98962599	+	IGF-1R	miR-515-5p	rs28674628	3'utr	A/G	A	genotyping/cloning and site-directed mutegenesis/transfection/luciferase reporter assay/RNA extraction/RT-qPCR/western blot/immunostaining	cell lines(HeLa, HEK-293T, MCF7, T47D, MDA-231, Hs578, BT-549)	lose	NULL	NULL	NULL	NULL	23549953	Involvement of IGF-1R regulation by miR-515-5p modifies breast cancer risk among BRCA1 carriers	The SNP rs28674628 disrupt the binding between miR-515-5p and IGF-1R, resulting in elevated IGF-1R expression levels. The high level of IGF-1R is associated with increase BC risk and earlier age.
chr3	119817870	119817871	+	PXR	miR-532-3p	rs1054190	3'utr	C/T	C	sequencing	blood tissue	NULL	Indian	case:96, control:0	T=0.0053	NULL	27644647	Screening for the 3'UTR Polymorphism of the PXR Gene in South Indian Breast Cancer Patients and its Potential Role in Pharmacogenomics	Genetic variants identified in PXR 3' UTR and their effects on PXR levels through post-transcriptional regulation provide a genetic basis for inter-individual variability in treatment response and toxicity associated with chemotherapy.
chr22	20111020	20111021	+	DGCRB	miR-579	rs417309	3'utr	G/A	G	SNP selection/genotyping/luciferase reporter plasmid/transient transfections and luciferase assay	blood tissue	decrease	Chinese women	case:1761, control:1853	A=0.0462	A=0.0318	23629745	Evaluation of genetic variants in microRNA biosynthesis genes and risk of breast cancer in Chinese women	SNP (rs417309) located in the 3'-UTR of DGCR8 was consistently associated with an increased breast cancer risk in two stages with a combined odds ratio (OR) of 1.50. DGCR8 rs417309 G>A may increase the risk of breast cancer through interrupting miRNA-106b or miRNA-579 binding affinity.
chr10	100975020	100975021	+	HSF1	miR-608	rs4919510	mature-miRNA	C/G	G	genotyping	blood tissue	decrease	Han Chinese women	case:1138, control:1434	C=0.4099	C=0.3878	22586447	Polymorphism rs4919510:C.G in Mature Sequence of Human MicroRNA-608 Contributes to the Risk of HER2- Positive Breast Cancer but Not Other Subtypes	Variant genotype of rs4919510 C>G located in mature miR-608 was associated with significantly increased risk of HER2+ breast cancer. A lower affinity of variant miR-608 to the binding sites in HSF1 3'UTR was found. 
chr10	100975020	100975021	+	NULL	miR-608	rs4919510	mature-miRNA	C/G	G	PCR-RFLP	blood tissue	NULL	Iranian	case:160, control:192	G=0.0625	G=0.1119	27031722	miR-608 rs4919510 C>G polymorphism decreased the risk of breast cancer in an Iranian subpopulation	Our findings indicate that miR-608 polymorphism might be associated with decreased risk of BC in an Iranian subpopulation. Further large-scale studies with different ethnicities are needed to verify our findings.
chr12	80935756	80935757	+	NULL	miR-618	rs2682818	pre-miRNA	C/A	C	genotyping	blood tissue	NULL	American	case:440, control:807	A=0.0954	A=0.0706	27421647	Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR-196a2, Pre-miR-423, miR-608 and Pre-miR-618 with breast cancer susceptibility in a South American population	The C/A genotype at rs2682818:C > A (pre-miR-618) increases BC risk in non-familial early-onset BC.
chr13	32398874	32398875	+	BRCA2	miR-627	rs15869	3'utr	A/C	A	PCR-RFLP/real-time PCR	blood tissue	NULL	Chinese	case:498, control:498	C=0.2729	C=0.2238	27807724	rs15869 at miRNA binding site in BRCA2 is associated with breast cancer susceptibility	Our findings suggest that the miRNA-binding SNPs in BRCA1/BRCA2 and their interaction with reproductive factors might contribute to BC risk, and miR-627 might down-regulate BRCA2 expression in MCF-7 and MDA-MB-231 cells.
chr9	99150188	99150189	+	TGFB1	miR-628-5p	rs334348	3'utr	A/G	G	DNA sequencing and SNP cloning/transfection and immunoblotting/luciferase assay	MCF7 cells, blood tissue	NULL	NULL	NULL	NULL	NULL	20332227	SINGLE NUCLEOTIDE POLYMORPHISMS INSIDE microRNA TARGET SITES INFLUENCE TUMOR SUSCEPTIBILITY	By over-expressing miR-628-5p in different cell lines, we observed that miR-628-5p behaves as a true repressor of TGFBR1 in a cell specific manner and that its repressor activity on TGFBR1 protein levels is dependent on the rs334348 variant inside the TGFBR1 3'UTR miRNA target sequence.
chr17	43092918	43092919	-	BRCA1	miR-638	rs799917	exon region of target gene	C/T	T	DNA sequencing and SNP cloning/transfection and immunoblotting/luciferase assay	MCF7 cells, blood tissue	NULL	NULL	NULL	NULL	NULL	20332227	SINGLE NUCLEOTIDE POLYMORPHISMS INSIDE microRNA TARGET SITES INFLUENCE TUMOR SUSCEPTIBILITY	miR-638 induced BRCA1 reduction according to rs799917 genotype, we observed that the presence of the CC genotype was responsible for a stronger reduction of BRCA1 protein levels.
chr4	168928237	168928238	+	PALLD	miR-96	rs1071738	3'utr	C/G	C	dual luciferase reporter assay/western blot/ 	HEK-293T, HeLa, Hs578, MCF-7 and T47D cell lines	NULL	NULL	NULL	NULL	NULL	27641360	Local microRNA delivery targets Palladin and prevents metastatic breast cancer	miR-96 downregulate Palladin protein levels, thereby reducing breast cancer cell migration and invasion. A common SNP, rs1071738, at the miR-96 binding site within the Palladin 3'-UTR abolishes miRNA:mRNA binding, thus diminishing Palladin regulation by these miRNAs. Our data corroborate the role of miRNAs in metastasis, and suggest miR-96/miR-182 delivery as a potential anti-metastatic drug.
chr1	26427450	26427451	-	LIN28	let-7	rs3811463	3'utr	T/C	A	luciferase reporter assay/real time PCR and western blot/SNP selection/genotyping/genotyping/immunohistochemistry/gene expression plasmid construct/soft agar assay/power analysis	breast tissue, cell lines (MDA-MB-231, MCF7, T47D, SK-BR-3, BT-474, MCF 10A, and HEK 293T)	decrease	Han Chinese	case:1004, control:1296	C=0.1619	C=0.1342	21912531	Disturbing the Let-7/LIN28 Double-Negative Feedback Loop Alter Breast Cancer Susceptibility	The C allele of rs3811463 weakened let-7 induced repression of LIN28 mRNA, resulting in increased production of LIN28 protein, which could in turn down-regulate the level of mature let-7. The C allele of the rs3811463 SNP corresponded to an increased risk of breast cancer.
