Cis-Methylated LncRNAs
( CML )
In the CML group, DNA methylation adjacent to/on the lncRNAs loci, such as the promoter or the imprinting control region, directly modulates the expression of target lncRNAs as a cis-regulator.
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Trans-Methylation Due to LncRNAs
( TMDL )
In the TMDL group, lncRNAs regulate the DNA methylation of a trans- genomic loci as an intermedium by recruiting the DNA (cytosine-5-)-methyltransferase (DNMT).
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Trans-Methylation Regulated LncRNAs
( TMRL )
In the TMRL group, alteration of the DNA methylation state in specific genomic loci regulates the transcription of its antisense-oriented lncRNAs.
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