Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieCardiac Hypertrophy
CeRNA1MIAT[LncRNA]
miRNAmiR-150[miRNA]
CeRNA2b-MHC[mRNA]
Tissue/Cell lineH9C2
SpecieMus musculus (mouse)
CitationEur Rev Med Pharmacol Sci 2016 Sep 20, 3653-60, PMID:27649667
Reference title
LncRNA MIAT enhances cardiac hypertrophy partly through sponging miR-150.
Experimental verification
qRT-PCR
Functional description
MIAT siRNA substantially alleviated the Ang II induced upregulation of ANP, BNP and b-MHC in H9c2 cells and markedly attenuated the Ang II induced increase of the cell surface area and the protein synthesis. MIAT overexpression in H9c2 cells significantly reduced the miR-150 expression.
Annotations
External Annotation for MIAT |
|
|---|---|
 |
LncRNA-associated competing triplets and functions. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
 |
Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
 |
Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
 |
Information on all annotated and predicted human genes. |
 |
Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
 |
Genome browser for vertebrate genomes. |
 |
An annotated collection of all publicly available DNA sequences. |
 |
A wiki-based platform for community curation of human long non-coding RNAs. |
 |
An integrated knowledge database dedicated to non-coding RNAs. |
 |
An integrated database of human annotated lncRNA transcripts. |
 |
Comprehensive annotations of eukaryotic long non-coding RNAs. |
 |
Comprehensive experimentally supported associations between lncRNA and human cancer. |
 |
A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
 |
The catalogue of somatic mutations in cancer. |
