Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieEmbryonic Stem Cell Pluripotency
CeRNA1AK048794[LncRNA]
miRNAmiR-592[miRNA]
CeRNA2FAM91A1[mRNA]
Tissue/Cell lineEmbryonic Stem Cells
SpecieMus musculus (mouse)
CitationBiochem J 2016 Oct 15 473, 3639-3654 doi:10.1042/bcj20160540 PMID:27520307
Reference title
AK048794 maintains the mouse embryonic stem cell pluripotency by functioning as an miRNA sponge for miR-592.
Experimental verification
RACE,luciferase reporter assays;Western blot assay
Functional description
We demonstrated that lncRNA - AK048794, regulated by transcription factor GATA1, functioned as a competing endogenous RNA (ceRNA) for miR-592 and led to the de-repression of its endogenous target FAM91A1, which is involved in mESC pluripotency maintenance.
Annotations
External Annotation for AK048794 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
