Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieAcute Promyelocytic Leukemia
CeRNA1c-Myc[Coding-mRNA]
miRNAlet-7a[miRNA]
CeRNA2RARA[mRNA]
Tissue/Cell lineNb4
SpecieMus musculus (mouse)
CitationOncotarget 2016 Aug 30 7, 56422-56430 doi:10.18632/oncotarget.10896 PMID:27486764
Reference title
C-Myc functions as a competing endogenous RNA in acute promyelocytic leukemia.
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot assay
Functional description
ttenuation of c-Myc transcript results in PML/RARa-degraded cellular phenotypes in APL cells, but these Myc reduction-associated cell phenotypes are sufficient to abrogate in a microRNA dependent manner. We also show that let-7microRNA family members promote differentiation of All-Trans-Retinoic Acid (ATRA)-induced NB4 cells and their activities are affected by expression levels of both c-Myc and PML/RARa through altering miRNA targets.
Annotations
External Annotation for c-Myc |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
