Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieOsteoarthritis
CeRNA1lncRNA-MSR[LncRNA]
miRNAmiR-152[miRNA]
CeRNA2TMSB4[mRNA]
Tissue/Cell lineOsteoarthritis Tissues
SpecieHomo sapiens (human)
CitationMol Ther 2016 Oct 24, 1726-1733 doi:10.1038/mt.2016.151 PMID:27469625
Reference title
The TMSB4 Pseudogene LncRNA Functions as a Competing Endogenous RNA to Promote Cartilage Degradation in Human Osteoarthritis.
Experimental verification
luciferase reporter assays;qRT-PCR;Northern blot assay;Western blot assay
Functional description
The TMSB4 pseudogene,lncRNA-MSR, was upregulated in the damaged cartilage and was activated in chondrocytes in response to mechanical stress. Furthermore,lncRNA-MSR regulated the expression of TMSB4 by competing with miRNA-152 in chondrocytes.
Annotations
External Annotation for lncRNA-MSR |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
