Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieHypoxic Human Mammospheres
CeRNA1CA9[LncRNA]
miRNAmiR-34a[miRNA]
CeRNA2NOTCH3[mRNA]
Tissue/Cell lineMcf7
SpecieHomo sapiens (human)
CitationJ Cell Physiol 2016 Jul 231, 1534-41 doi:10.1002/jcp.25245 PMID:26553365
Reference title
Carbonic Anhydrase 9 mRNA/microRNA34a Interplay in hypoxic human mammospheres.
Experimental verification
luciferase reporter assays;qRT-PCR
Functional description
The over-expression of cloned CA9-mRNA-3'UTR increases the mRNA half-life and protein levels of two miR34a targets JAGGED1 and NOTCH3. The data here reported shows that the SNAI2-dependent down-regulation of miR34a substantially contributes to the post-transcriptional up-regulation of CA9, and that CA9-mRNA-3'UTR acts as an endogenous microRNA sponge.
Annotations
External Annotation for CA9 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
