Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieBladder Cancer
CeRNA1H19[LncRNA]
miRNAmiR-29a-3p[miRNA]
CeRNA2ITGB1[mRNA]
Tissue/Cell lineBladder Carcinoma Tissues
SpecieHomo sapiens (human)
CitationOncotarget 2016 Jul 26 7, 47186-47200 doi:10.18632/oncotarget.9706 PMID:27363013
Reference title
Comprehensive analysis of differentially expressed profiles of lncRNAs and circRNAs with associated co-expression and ceRNA networks in bladder carcinoma.
Experimental verification
microarray;qRT-PCR
Functional description
We selected differentially expressed 8 lncRNAs and 9 circRNAs, sharing a common binding site of MRE. For instance, lncRNA H19, circular MYLK and circular CTDP1 are ceRNA of miR-29a-3p targeting DNMT3B, ITGB1, VEGFA and HAS3. Whereas, lncRNA RP11-89K21.2 and circular PC are ceRNA of miR-185-3p targeting ADD1and BAP1. These RNA interactions would supply novel perspective for the tumorigenesis mechanisms of BC.
Annotations
External Annotation for H19 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
