Basic Information
Regular Relationship :
Phenotype/DiseaseSpecieIntestinal Barrier Dysfunction
CeRNA1H19[LncRNA]
miRNAmiR-874[miRNA]
CeRNA2AQP3[mRNA]
Tissue/Cell lineCaco-2 Cells
SpecieHomo sapiens (human)
CitationFEBS Lett 2016 May 590, 1354-64 doi:10.1002/1873-3468.12171 PMID:27059301
Reference title
LncRNA H19 functions as a competing endogenous RNA to regulate AQP3 expression by sponging miR-874 in the intestinal barrier.
Experimental verification
luciferase reporter assays;qRT-PCR;Western blot assay
Functional description
H19 function as a competing endogenous RNA (ceRNA) to regulate the expression of AQP3 through competition for miR-874, thus playing a significant role in maintaining intestinal barrier function.
Annotations
External Annotation for H19 |
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LncRNA-associated competing triplets and functions. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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Infer genomic variations that disturb lncRNA-associated ceRNA regulation.. |
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Provide and annotate disease or phenotype-associated variants in human long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) or their regulatory elements. |
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Providing cellular-specific lncRNA-associated ceRNA networks predicted via high-throughput analysis of single-cell genomic data. |
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Information on all annotated and predicted human genes. |
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Gene nomenclature, gene families and associated resources (genomic, proteomic, phenotypic information). |
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Genome browser for vertebrate genomes. |
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An annotated collection of all publicly available DNA sequences. |
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A wiki-based platform for community curation of human long non-coding RNAs. |
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An integrated knowledge database dedicated to non-coding RNAs. |
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An integrated database of human annotated lncRNA transcripts. |
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Comprehensive annotations of eukaryotic long non-coding RNAs. |
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Comprehensive experimentally supported associations between lncRNA and human cancer. |
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A comprehensive, authoritative compendium of human genes and genetic phenotypes. |
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The catalogue of somatic mutations in cancer. |
